Rare genetic inflammatory skin disorders

Gene: IL36RN

Green List (high evidence)

IL36RN (interleukin 36 receptor antagonist)
EnsemblGeneIds (GRCh38): ENSG00000136695
EnsemblGeneIds (GRCh37): ENSG00000136695
OMIM: 605507, Gene2Phenotype
IL36RN is in 7 panels

2 reviews

Tom Cullup (Great Ormond Street Hospital)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal



Rebecca Foulger (Genomics England curator)

Green List (high evidence)

This gene was part of an initial gene list collated by Thomas Cullup, GOSH and Veronica Kinsler, UCL, 25.Jan.2019 on behalf of the GMS Skin Specialist Test Group. Gene Symbol submitted: IL36RN; Suggested initial gene rating: Green; Evidence for inclusion: none provided; Evidence for exclusion: none provided; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none provided.
Created: 31 Jan 2019, 2:02 p.m.

Variants in this GENE are reported as part of current diagnostic practice


Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • London North GLH
  • Expert Review Green
  • Psoriasis 14, pustular, OMIM:614204
Clinvar variants
Variants in IL36RN
Panels with this gene

History Filter Activity

10 Jan 2022, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: IL36RN were changed from PSORIASIS 14, PUSTULAR, OMIM:614204 to Psoriasis 14, pustular, OMIM:614204

24 Mar 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: IL36RN were changed from PSORS14; PSORIASIS 14, PUSTULAR; Recurrent pustular psoriasis to PSORIASIS 14, PUSTULAR, OMIM:614204

12 Dec 2019, Gel status: 3

Set Phenotypes, Set publications

Catherine Snow (Genomics England)

Added phenotypes PSORIASIS 14, PUSTULAR; PSORS14 for gene: IL36RN Publications for gene IL36RN were changed from to 22903787

18 Feb 2019, Gel status: 4

Added New Source

Rebecca Foulger (Genomics England curator)

Source London North GLH was added to IL36RN.

31 Jan 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: IL36RN was added gene: IL36RN was added to Rare genetic inflammatory skin disorders. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: IL36RN was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: IL36RN were set to Recurrent pustular psoriasis