Inherited breast cancer and ovarian cancer
Gene: ATM
ATM (ATM serine/threonine kinase)
EnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 32 panels
EnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 32 panels
1 review
Arina Puzriakova (Genomics England Curator)
This gene has been added to the panel on the recommendation of the NHS Genomic Medicine Service and should be rated green.Created: 8 Mar 2022, 11:40 a.m. | Last Modified: 8 Mar 2022, 11:40 a.m.
Panel Version: 0.9
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Phenotypes
-
- {Breast cancer, susceptibility to}, OMIM:114480
- OMIM
- 607585
- Clinvar variants
- Variants in ATM
- Penetrance
- None
- Publications
- Panels with this gene
-
- Familial breast cancer
- Inherited prostate cancer
- Brain cancer pertinent cancer susceptibility
- Primary ovarian insufficiency
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Inherited pancreatic cancer
- Ataxia and cerebellar anomalies - narrow panel
- Haematological malignancies for rare disease
- Adult onset neurodegenerative disorder
- Intellectual disability
- Hereditary ataxia with onset in adulthood
- Ataxia telangiectasia - mutation testing
- Childhood onset dystonia, chorea or related movement disorder
- Hereditary ataxia
- DDG2P
- Hereditary neuropathy
- Fetal anomalies
- Childhood solid tumours cancer susceptibility
- Haematological malignancies cancer susceptibility
- Inherited breast cancer and ovarian cancer
- Vascular skin disorders
- Familial Tumours Syndromes of the central & peripheral Nervous system
- COVID-19 research
- Childhood solid tumours
- Adult solid tumours for rare disease
- Sarcoma susceptibility
- Early onset dystonia
- Adult solid tumours cancer susceptibility
- Adult onset dystonia, chorea or related movement disorder
- Inherited ovarian cancer (without breast cancer)
- Hereditary neuropathy or pain disorder
- Hereditary haemorrhagic telangiectasia
History Filter Activity
8 Mar 2022, Gel status: 3
Set publications
Arina Puzriakova (Genomics England Curator)Publications for gene: ATM were set to {Breast cancer, susceptibility to}, OMIM:114480
8 Mar 2022, Gel status: 3
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: ATM were changed from to {Breast cancer, susceptibility to}, OMIM:114480
8 Mar 2022, Gel status: 3
Created, Added New Source, Set mode of inheritance, Set publications
Arina Puzriakova (Genomics England Curator)gene: ATM was added gene: ATM was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ATM were set to {Breast cancer, susceptibility to}, OMIM:114480