Rhabdomyolysis and metabolic muscle disorders
Gene: CYP2C8

CYP2C8 (cytochrome P450 family 2 subfamily C member 8)
EnsemblGeneIds (GRCh38): ENSG00000138115
EnsemblGeneIds (GRCh37): ENSG00000138115
OMIM: 601129, Gene2Phenotype
CYP2C8 is in 2 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Pharmacogenetic tag added as variants in CYP2C8 are associated with cerivastatin induced rhabdomyolysis
Created: 4 Jan 2017, 1:10 p.m.

Comment on phenotypes: Variants in CYP2C8 associated with cerivastatin induced rhabdomyolysis and are therefore not relevant to inherited rhabdomyolysis.
Created: 4 Jan 2017, 1:09 p.m.

Created: 4 Jan 2017, 1:10 p.m.

Panel version: 0.99

Ros Quinlivan (UCLH)

Green List (high evidence)

Created: 4 Jan 2017, 11:20 a.m.

Panel version: 0.81

Details

Mode of Inheritance

Unknown

Sources

Radboud University Medical Center, Nijmegen

Phenotypes

{Drug metabolism, altered, CYP2C8-related}, OMIM:618018
Rhabdomyolysis, cerivastatin-induced

Tags

pharmacogenetics

OMIM

601129

Clinvar variants

Variants in CYP2C8

Penetrance

Complete

Publications

Panels with this gene

History Filter Activity

13 Jan 2022, Gel status: 1

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: CYP2C8 were changed from Rhabdomyolysis, cerivastatin-induced to {Drug metabolism, altered, CYP2C8-related}, OMIM:618018; Rhabdomyolysis, cerivastatin-induced

4 Jan 2017, Gel status: 1