Rhabdomyolysis and metabolic muscle disorders
Gene: TANGO2Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).Created: 20 Oct 2020, 3:10 p.m. | Last Modified: 20 Oct 2020, 3:10 p.m.
Panel Version: 1.43
The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 8 Mar 2022, 4:51 p.m. | Last Modified: 8 Mar 2022, 4:51 p.m.
Panel Version: 1.77
Gene suggested by Rowenna Roberts, Clinical Scientist.Created: 5 May 2020, 11:15 a.m. | Last Modified: 5 May 2020, 11:15 a.m.
Panel Version: 1.39
Associated with relevant phenotype in OMIM and as confirmed Gen2Phen gene. At least 10 variants reported in at least 14 unrelated cases, in which rabdomyolysis was reported in 11 unrelated cases.
Sources: Expert ReviewCreated: 5 May 2020, 11:01 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 616878
Publications
Phenotypes for gene: TANGO2 were changed from Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 616878 to Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, OMIM:616878
Tag for-review was removed from gene: TANGO2.
Source Expert Review Green was added to TANGO2. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: tango2 has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: TANGO2.
Gene: tango2 has been classified as Green List (High Evidence).
gene: TANGO2 was added gene: TANGO2 was added to Rhabdomyolysis and metabolic muscle disorders. Sources: Expert Review Mode of inheritance for gene: TANGO2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TANGO2 were set to 26805782; 30245509 Phenotypes for gene: TANGO2 were set to Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 616878 Review for gene: TANGO2 was set to GREEN