Rhabdomyolysis and metabolic muscle disorders

Gene: CYP2C8

Red List (low evidence)

CYP2C8 (cytochrome P450 family 2 subfamily C member 8)
EnsemblGeneIds (GRCh38): ENSG00000138115
EnsemblGeneIds (GRCh37): ENSG00000138115
OMIM: 601129, Gene2Phenotype
CYP2C8 is in 2 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Pharmacogenetic tag added as variants in CYP2C8 are associated with cerivastatin induced rhabdomyolysis
Created: 4 Jan 2017, 1:10 p.m.
Comment on phenotypes: Variants in CYP2C8 associated with cerivastatin induced rhabdomyolysis and are therefore not relevant to inherited rhabdomyolysis.
Created: 4 Jan 2017, 1:09 p.m.

Ros Quinlivan (UCLH)

Green List (high evidence)

Details

Mode of Inheritance
Unknown
Sources
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Rhabdomyolysis, cerivastatin-induced
Tags
pharmacogenetics
OMIM
601129
Clinvar variants
Variants in CYP2C8
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

4 Jan 2017, Gel status: 1

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Panel promoted to V1 4th January 2017

4 Jan 2017, Gel status: 1

Set Mode of Inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for CYP2C8 was changed to Unknown

4 Jan 2017, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for CYP2C8 were set to 15365880; 20739906

4 Jan 2017, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for CYP2C8 were set to Rhabdomyolysis, cerivastatin-induced

4 Jan 2017, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for CYP2C8 were set to 15365880

27 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

CYP2C8 was added to Rhabdomyolysis and metabolic muscle disorders panel. Sources: Radboud University Medical Center, Nijmegen