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  3. KCNE2
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Sudden cardiac death - previous panel

Gene: KCNE2

Green List (high evidence)
KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2)
EnsemblGeneIds (GRCh38): ENSG00000159197
EnsemblGeneIds (GRCh37): ENSG00000159197
OMIM: 603796, Gene2Phenotype
KCNE2 is in 2 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.
Created: 20 Feb 2019, 2:17 p.m.
Created: 20 Feb 2019, 2:17 p.m.

Panel version: Imported from Molecular autopsy panel version 0.86

James Eden (Manchester)

Green List (high evidence)

Gene currently tested on Manchester cardiac gene panel. 25 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: gene not curated (accessed 29/01/2019).
Created: 14 Feb 2019, 1:38 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Long QT syndrome-6 (613693); Atrial fibrillation, familial, 4 (611493)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 14 Feb 2019, 1:38 p.m.

Panel version: Imported from Molecular autopsy panel version 0.82

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • London South GLH
  • North West GLH
  • Expert Review Green
  • London South GLH
  • North West GLH
  • Expert Review Green
Phenotypes
  • Long QT syndrome-6 (613693)
  • Long QT syndrome-6
  • Atrial fibrillation, familial, 4 (611493)
OMIM
603796
Clinvar variants
Variants in KCNE2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

9 Sep 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: KCNE2 was added gene: KCNE2 was added to Sudden cardiac death. Sources: Expert Review Green,North West GLH,London South GLH Mode of inheritance for gene: KCNE2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: KCNE2 were set to 19716085; 16301704 Phenotypes for gene: KCNE2 were set to Long QT syndrome-6 (613693); Long QT syndrome-6; Atrial fibrillation, familial, 4 (611493)