Sudden cardiac death - previous panel
Gene: TMPO
This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.Created: 20 Feb 2019, 2:17 p.m.
Gene currently tested on Manchester cardiac gene panel. Only class 1-3 variants detected to date. 13 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: refuted association with dilated cardiomyopathy 1T (accessed 29/01/2019).Created: 14 Feb 2019, 1:38 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Dilated Cardiomyopathy, Dominant
Publications
Variants in this GENE are reported as part of current diagnostic practice
gene: TMPO was added gene: TMPO was added to Sudden cardiac death. Sources: Expert Review Red,North West GLH,London South GLH Mode of inheritance for gene: TMPO was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: TMPO were set to 16247757 Phenotypes for gene: TMPO were set to Dilated Cardiomyopathy, Dominant