Clefting
Gene: DLX4
Only one family to date. Further evidence needed re causationCreated: 26 May 2017, 7:40 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
OROFACIAL CLEFT 15; OFC15
Comment on publications: Orofacial cleft-15 (OFC15) is caused by mutation in the DLX4 gene (601911) on chromosome 17q21. One such family has been reported.Created: 24 Jan 2017, 3:18 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
CLP
Panel reviews were assessed, and panel was revised according to reviews and further curation 31st May 2017
DLX4 was added to Cleftingpanel. Source: Expert Review Amber Model of inheritance for gene DLX4 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DLX4All sources for gene: DLX4 were removed
Phenotypes for gene DLX4 were set to ?Orofacial cleft 15, 616788;nonsyndromic cleft/lip palate (CL/P)
Publications for DLX4 were set to 25954033
Phenotypes for DLX4 were set to ?Orofacial cleft 15,616788; nonsyndromic cleft/lip palate (CL/P)
Publications for DLX4 were set to 25954033
Mode of inheritance for DLX4 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DLX4 was added to Cleftingpanel. Sources: Radboud University Medical Center, Nijmegen
DLX4 was created by oniblock