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Membranoproliferative glomerulonephritis

Gene: CFI

Green List (high evidence)

CFI (complement factor I)
EnsemblGeneIds (GRCh38): ENSG00000205403
EnsemblGeneIds (GRCh37): ENSG00000205403
OMIM: 217030, Gene2Phenotype
CFI is in 6 panels

4 reviews

Eleanor Williams (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Valerie Wilson, The National Renal Complement Therapeutics Centre, February 2019 on behalf of Yorkshire and North East GLH for the GMS Renal Specialist Test Group; Gene Symbol submitted: CFI; Suggested initial gene rating: none provided;
Created: 12 Feb 2019, 12:13 p.m.

Arianna Tucci (Genomics England Curator)

Comment when marking as ready: Marked as ready after clinical review
Created: 15 Dec 2017, 3:40 p.m.

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
C3 glomerulopathy; C3G; Immune complex MPGN; IC-MPGN

Publications

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Pertinent gene. The variants known to be associated to MPGN - Genes against which can be detected with current pipeline (Single nucleotide variants/frameshifts/premature stop codon etc)
Created: 5 Jun 2017, 2:43 p.m.

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert list
Phenotypes
  • C3 glomerulopathy
  • C3G
  • Immune complex MPGN
  • IC-MPGN
  • Immune-complex-mediated MPGN
  • Hemolytic uremic syndrome, atypical, susceptibility to, 3,612923
OMIM
217030
Clinvar variants
Variants in CFI
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

12 Feb 2019, Gel status: 3

Added New Source, Status Update

Eleanor Williams (Genomics England Curator)

Source NHS GMS was added to CFI. Rating Changed from Green List (high evidence) to Green List (high evidence)

15 Dec 2017, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

15th December 2017. Panel reviews were assessed, and panel was revised according to reviews and further curation by Arianna Tucci and Louise Daugherty

15 Dec 2017, Gel status: 3

Gene classified by Genomics England curator

Arianna Tucci (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

5 Jun 2017, Gel status: 4

Gene classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

5 Jun 2017, Gel status: 0

Added New Source

Anonymous ()

CFI was added to Primary Membranoproliferative Glomerulonephritispanel. Sources: Expert list

5 Jun 2017, Gel status: 0

Created

Anonymous ()

CFI was created by Anonymous