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Cardiac arrhythmias - additional genes

Gene: ANK2

Red List (low evidence)

ANK2 (ankyrin 2)
EnsemblGeneIds (GRCh38): ENSG00000145362
EnsemblGeneIds (GRCh37): ENSG00000145362
OMIM: 106410, Gene2Phenotype
ANK2 is in 13 panels

3 reviews

Arina Puzriakova (Genomics England Curator)

Red List (low evidence)

The rating of this gene has been updated to Red following NHS Genomic Medicine Service approval.
Created: 30 Jan 2023, 11:48 a.m. | Last Modified: 30 Jan 2023, 11:48 a.m.
Panel Version: 2.4

Zornitza Stark (Australian Genomics)

Red List (low evidence)

DISPUTED by ClinGen.
Created: 7 Aug 2021, 6:25 a.m. | Last Modified: 7 Aug 2021, 6:25 a.m.
Panel Version: 1.11

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Long QT syndrome 4, MIM# 600919

Publications

Ivone Leong (Genomics England Curator)

Green List (high evidence)

Sources: NHS GMS
Created: 4 Dec 2019, 10:45 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Long QT syndrome 4, 600919; Cardiac arrhythmia, ankyrin-B-related, 600919

History Filter Activity

30 Jan 2023, Gel status: 1

Removed Tag, Removed Tag

Arina Puzriakova (Genomics England Curator)

Tag Q3_22_rating was removed from gene: ANK2. Tag Q3_22_expert_review was removed from gene: ANK2.

30 Jan 2023, Gel status: 1

Added New Source, Status Update

Arina Puzriakova (Genomics England Curator)

Source Expert Review Red was added to ANK2. Rating Changed from Green List (high evidence) to Red List (low evidence)

5 Oct 2022, Gel status: 3

Removed Tag, Added Tag, Added Tag

Eleanor Williams (Genomics England Curator)

Tag Q3_21_expert_review was removed from gene: ANK2. Tag Q3_22_rating tag was added to gene: ANK2. Tag Q3_22_expert_review tag was added to gene: ANK2.

10 Aug 2021, Gel status: 3

Added Tag

Ivone Leong (Genomics England Curator)

Tag Q3_21_expert_review tag was added to gene: ANK2.

10 Aug 2021, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: ANK2 were set to

4 Dec 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: ank2 has been classified as Green List (High Evidence).

4 Dec 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: ANK2 was added gene: ANK2 was added to Cardiac arrhythmias - additional genes. Sources: NHS GMS Mode of inheritance for gene: ANK2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: ANK2 were set to Long QT syndrome 4, 600919; Cardiac arrhythmia, ankyrin-B-related, 600919 Review for gene: ANK2 was set to GREEN