Parathyroid Cancer
Gene: MEN1
MEN1 (menin 1)
EnsemblGeneIds (GRCh38): ENSG00000133895
EnsemblGeneIds (GRCh37): ENSG00000133895
OMIM: 613733, Gene2Phenotype
MEN1 is in 16 panels
EnsemblGeneIds (GRCh38): ENSG00000133895
EnsemblGeneIds (GRCh37): ENSG00000133895
OMIM: 613733, Gene2Phenotype
MEN1 is in 16 panels
3 reviews
Katie Snape (South London GMC)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Louise IZATT (GSTT Clinical Genetics Service)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Ellen Thomas (Genomics England Curator)
Comment on list classification: Robust association with overlapping phenotype.Created: 14 Feb 2016, 4:19 p.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- UKGTN
- Radboud University Medical Center, Nijmegen
- Phenotypes
-
- Multiple endocrine neoplasia 1, 131100
- Carcinoid tumor of lung
- Parathyroid adenoma, somatic
- Lipoma, somatic
- Angiofibroma, somatic
- Adrenal adenoma, somatic
- Pituitary Cancer, Parathyroid and Hypercalcemia
- OMIM
- 613733
- Clinvar variants
- Variants in MEN1
- Penetrance
- Complete
- Panels with this gene
-
- Inherited phaeochromocytoma and paraganglioma
- Additional findings health related - children
- Familial Tumours Syndromes of the central & peripheral Nervous system
- Parathyroid Cancer
- Familial hyperparathyroidism or hypocalciuric hypercalcaemia
- Childhood solid tumours
- Adult solid tumours for rare disease
- Adult solid tumours cancer susceptibility
- Multiple endocrine tumours
- Endocrine neoplasia
- Additional findings health related - CNV analysis children
- Inherited phaeochromocytoma and paraganglioma excluding NF1
- Inherited non-medullary thyroid cancer
- Additional findings health related
- Neuroendocrine cancer pertinent cancer susceptibility
- Childhood solid tumours cancer susceptibility
History Filter Activity
14 Feb 2016, Gel status: 4
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
14 Feb 2016, Gel status: 4
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for MEN1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
14 Feb 2016, Gel status: 4
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
18 Aug 2015, Gel status: 2
Added New Source
Ellen McDonagh (Genomics England Curator)MEN1 was added to Parathyroid Cancerpanel. Source: UKGTN
18 Aug 2015, Gel status: 1
Added New Source
Ellen McDonagh (Genomics England Curator)MEN1 was added to Parathyroid Cancerpanel. Sources: Radboud University Medical Center, Nijmegen,UKGTN