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Proteinuric renal disease v2.68 DGKE Eleanor Williams Phenotypes for gene: DGKE were changed from Nephrotic syndrome, type 7 #615008 to Nephrotic syndrome, type 7, OMIM:615008
Proteinuric renal disease v2.67 DGKE Eleanor Williams Tag for-review was removed from gene: DGKE.
Proteinuric renal disease v2.66 DGKE Eleanor Williams commented on gene: DGKE: The rating of this gene has been updated following NHS Genomic Medicine Service approval. The reviewers note and overlap with aHUS
Proteinuric renal disease v2.65 DGKE Eleanor Williams Source Expert Review Green was added to DGKE.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Proteinuric renal disease v2.30 DGKE Catherine Snow Classified gene: DGKE as Amber List (moderate evidence)
Proteinuric renal disease v2.30 DGKE Catherine Snow Added comment: Comment on list classification: Changed rating to Amber to reflect NHS signed-off rating, will be examined at next panel review.
Proteinuric renal disease v2.30 DGKE Catherine Snow Gene: dgke has been classified as Amber List (Moderate Evidence).
Proteinuric renal disease v2.26 DGKE Eleanor Williams Tag for-review tag was added to gene: DGKE.
Proteinuric renal disease v2.15 DGKE Eleanor Williams Classified gene: DGKE as Green List (high evidence)
Proteinuric renal disease v2.15 DGKE Eleanor Williams Added comment: Comment on list classification: Changing rating to green as multiple cases reported and expert review says proteinuria is a prominent feature
Proteinuric renal disease v2.15 DGKE Eleanor Williams Gene: dgke has been classified as Green List (High Evidence).
Proteinuric renal disease v2.14 DGKE Eleanor Williams Mode of inheritance for gene: DGKE was changed from to BIALLELIC, autosomal or pseudoautosomal
Proteinuric renal disease v2.6 DGKE Catherine Snow Classified gene: DGKE as Amber List (moderate evidence)
Proteinuric renal disease v2.6 DGKE Catherine Snow Gene: dgke has been classified as Amber List (Moderate Evidence).
Proteinuric renal disease v2.0 DGKE Eleanor Williams edited their review of gene: DGKE: Added comment: Associated with Nephrotic syndrome, type 7 #615008 (AR) in OMIM.

PMID: 23542698 - Lemaire et al 2013 - 9 families identified with homozgyous or compound heterozygous variants in DGKE. All were cases of pediatric-onset aHUS. One variant was found in on both alleles in 3 families (p.Trp322*) and heterozygously in 2 others and the families are thought to have a remote shared ancestry. Three patients from different families developed nephrotic syndrome 3-5 years after disease onset.

PMID: 23274426 - Ozaltin et al 2013 - 3 consanguineous families - 3 different homozygous variants in 9 individuals. Table 1 gives proteinuria levels at onset.; Changed publications: PMID: 23274426, PMID: 23542698
Proteinuric renal disease v2.0 DGKE Zornitza Stark reviewed gene: DGKE: Rating: GREEN; Mode of pathogenicity: None; Publications: 23542698, 23274426; Phenotypes: Nephrotic syndrome, type 7, MIM# 615008; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Proteinuric renal disease v1.144 DGKE Eleanor Williams Phenotypes for gene: DGKE were changed from to Nephrotic syndrome, type 7 #615008
Proteinuric renal disease v1.143 DGKE Eleanor Williams Publications for gene: DGKE were set to
Proteinuric renal disease v1.16 DGKE Eleanor Williams reviewed gene: DGKE: Rating: AMBER; Mode of pathogenicity: ; Publications: PMID: 23274426, PMID: 23542698; Phenotypes: Nephrotic syndrome, type 7 #615008; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Proteinuric renal disease v1.15 DGKE Eleanor Williams gene: DGKE was added
gene: DGKE was added to Proteinuric renal disease. Sources: NHS GMS
Mode of inheritance for gene: DGKE was set to