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Mitochondrial disorders v6.4 COX11 Achchuthan Shanmugasundram Tag Q4_23_promote_green was removed from gene: COX11.
Mitochondrial disorders v6.3 COX11 Sarah Leigh edited their review of gene: COX11: Added comment: The rating of this gene has been updated to green and the mode of inheritance updated to BIALLELIC, autosomal or pseudoautosomal following NHS Genomic Medicine Service approval.; Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders v6.2 COX11 Achchuthan Shanmugasundram Source Expert Review Green was added to COX11.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Mitochondrial disorders v4.143 COX11 Sarah Leigh Classified gene: COX11 as Amber List (moderate evidence)
Mitochondrial disorders v4.143 COX11 Sarah Leigh Added comment: Comment on list classification: There is enough evidence for this gene to be rated GREEN at the next major review.
Mitochondrial disorders v4.143 COX11 Sarah Leigh Gene: cox11 has been classified as Amber List (Moderate Evidence).
Mitochondrial disorders v4.142 COX11 Sarah Leigh Classified gene: COX11 as Amber List (moderate evidence)
Mitochondrial disorders v4.142 COX11 Sarah Leigh Gene: cox11 has been classified as Amber List (Moderate Evidence).
Mitochondrial disorders v4.141 COX11 Sarah Leigh Tag Q4_23_promote_green tag was added to gene: COX11.
Mitochondrial disorders v4.141 COX11 Sarah Leigh edited their review of gene: COX11: Added comment: COX11 variants have been associated with Mitochondrial complex IV deficiency, nuclear type 23 (OMIM:620275), but not with a phenotype in Gen2Phen. At least four COX11 variants have been reported in three unrelated cases of OMIM:620275 (PMIDs: 36030551;38068960), together with supportive functional studies in patient's fibroblasts and Saccharomyces cerevisiae.; Changed rating: GREEN
Mitochondrial disorders v4.141 COX11 Sarah Leigh Mode of inheritance for gene: COX11 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders v4.140 COX11 Sarah Leigh Phenotypes for gene: COX11 were changed from Mitochondrial complex IV deficiency, nuclear type 23, OMIM:620275; Mitochondrial complex IV deficiency, nuclear type 23, MONDO:0859520 to Mitochondrial complex IV deficiency, nuclear type 23, OMIM:620275; Mitochondrial complex IV deficiency, nuclear type 23, MONDO:0859520
Mitochondrial disorders v4.139 COX11 Sarah Leigh Publications for gene: COX11 were set to 36030551; 38068960
Mitochondrial disorders v4.138 COX11 Sarah Leigh Publications for gene: COX11 were set to 36030551
Mitochondrial disorders v4.137 COX11 Sarah Leigh Publications for gene: COX11 were set to
Mitochondrial disorders v4.136 COX11 Sarah Leigh Mode of inheritance for gene: COX11 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders v4.135 COX11 Sarah Leigh Phenotypes for gene: COX11 were changed from No OMIM phenotype to Mitochondrial complex IV deficiency, nuclear type 23, OMIM:620275; Mitochondrial complex IV deficiency, nuclear type 23, MONDO:0859520
Mitochondrial disorders v2.109 COX11 Arina Puzriakova commented on gene: COX11
Mitochondrial disorders v2.108 COX11 Arina Puzriakova Source Expert Review Red was added to COX11.
Rating Changed from Amber List (moderate evidence) to Red List (low evidence)
Mitochondrial disorders v2.5 COX11 Zornitza Stark reviewed gene: COX11: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Mitochondrial disorders v1.412 COX11 Sarah Leigh reviewed gene: COX11: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Mitochondrial disorders v1.411 COX11 Sarah Leigh gene: COX11 was added
gene: COX11 was added to Mitochondrial disorders. Sources: NHS GMS,Expert Review Amber
Mode of inheritance for gene: COX11 was set to Unknown
Phenotypes for gene: COX11 were set to No OMIM phenotype