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Mitochondrial disorders v3.6 PDK3 Achchuthan Shanmugasundram Tag Q1_22_phenotype was removed from gene: PDK3.
Tag Q2_22_rating was removed from gene: PDK3.
Tag Q2_22_expert_review was removed from gene: PDK3.
Mitochondrial disorders v3.6 PDK3 Achchuthan Shanmugasundram changed review comment from: After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed and remains Red.; to: After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed and remains Red.

Note from GMS reviewers: Phenotype from mutations from this gene is not that of Mitochondrial disease - appropriate to be green on Neuropathy panel(NT). Not sure there is sufficient evidence that this can be classified as primary mitochondrial disease, but may be appropriate to include elsewhere in white matter disorders panel (C&S).
Mitochondrial disorders v3.6 PDK3 Achchuthan Shanmugasundram reviewed gene: PDK3: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Mitochondrial disorders v2.107 PDK3 Sarah Leigh Tag Q2_22_rating tag was added to gene: PDK3.
Mitochondrial disorders v2.107 PDK3 Sarah Leigh Tag Q2_22_expert_review tag was added to gene: PDK3.
Mitochondrial disorders v2.80 PDK3 Arina Puzriakova Publications for gene: PDK3 were set to
Mitochondrial disorders v2.79 PDK3 Arina Puzriakova reviewed gene: PDK3: Rating: ; Mode of pathogenicity: None; Publications: 23297365, 26801680, 27388934, 28902413, 32504000, 34387338; Phenotypes: Charcot-Marie-Tooth disease, X-linked dominant, 6, OMIM:300905; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Mitochondrial disorders v2.79 PDK3 Arina Puzriakova Tag Q1_22_phenotype tag was added to gene: PDK3.
Mitochondrial disorders v2.79 PDK3 Arina Puzriakova Mode of inheritance for gene: PDK3 was changed from to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Mitochondrial disorders PDK3 Zornitza Stark reviewed gene: PDK3