| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Familial breast cancer v1.20 | ATRIP | Arina Puzriakova Mode of inheritance for gene: ATRIP was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Familial breast cancer v1.19 | ATRIP | Arina Puzriakova Classified gene: ATRIP as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Familial breast cancer v1.19 | ATRIP | Arina Puzriakova Added comment: Comment on list classification: New gene added to this panel by Lauma Freimane. More evidence is required prior to adding this gene to the panel. The metanalysis paper identified by reviewer is still at the preprint stage. The findings are detailed below but this needs to be revisited once the article has been published. This is a good candidate gene for breast cancer susceptibility but for now can only classify as Amber (with watchlist tag), awaiting peer-review and additional publication of supporting evidence. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Familial breast cancer v1.19 | ATRIP | Arina Puzriakova Gene: atrip has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Familial breast cancer v1.18 | ATRIP | Arina Puzriakova commented on gene: ATRIP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Familial breast cancer v1.18 | ATRIP |
Lauma Freimane gene: ATRIP was added gene: ATRIP was added to Familial breast cancer. Sources: Literature Mode of inheritance for gene: ATRIP was set to Unknown Publications for gene: ATRIP were set to 36977412 Phenotypes for gene: ATRIP were set to Hereditary breast cancer Review for gene: ATRIP was set to GREEN gene: ATRIP was marked as current diagnostic Added comment: Meta-analysis confirms ATRIP role in breast cancer development (https://doi.org/10.1101/2022.06.17.22276537). Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank. Sources: Literature |
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