23 Aug 2021
Hereditary spastic paraplegia v1.253
TFG
Arina Puzriakova Phenotypes for gene: TFG were changed from Hereditary spastic paraplegia - childhood onset; Intellectual disability; Hereditary spastic paraplegia - adult onset; neuropathy to Spastic paraplegia 57, autosomal recessive, OMIM:615658
23 Aug 2021
Hereditary spastic paraplegia v1.252
TFG
Arina Puzriakova Publications for gene: TFG were set to 23479643; 27601211; 28124177; 27492651
10 Jan 2020
Hereditary spastic paraplegia v1.213
TFG
Louise Daugherty edited their review of gene: TFG: Changed rating: GREEN
10 Jan 2020
Hereditary spastic paraplegia v1.213
TFG
Louise Daugherty Classified gene: TFG as Green List (high evidence)
10 Jan 2020
Hereditary spastic paraplegia v1.213
TFG
Louise Daugherty Added comment: Comment on list classification: Upgraded gene from Amber to Green due to feedback from Genomics England clinical team, due to re-analysing a few cases for diagnostic discovery there is enough evidence to support a Green rating on this panel.
10 Jan 2020
Hereditary spastic paraplegia v1.213
TFG
Louise Daugherty Gene: tfg has been classified as Green List (High Evidence).
10 Jan 2020
Hereditary spastic paraplegia v1.212
TFG
Louise Daugherty Phenotypes for gene: TFG were changed from to Hereditary spastic paraplegia - childhood onset; Intellectual disability; Hereditary spastic paraplegia - adult onset; neuropathy
10 Jan 2020
Hereditary spastic paraplegia v1.211
TFG
Louise Daugherty Added comment: Comment on publications: added publications to support upgrading from Amber to Green.
10 Jan 2020
Hereditary spastic paraplegia v1.211
TFG
Louise Daugherty Publications for gene: TFG were set to Beetz et al. (2013)
07 Jan 2020
Hereditary spastic paraplegia v1.210
TFG
Zerin Hyder reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 23479643, 27601211, 28124177, 27492651; Phenotypes: Hereditary spastic paraplegia - childhood onset, Intellectual disability, Hereditary spastic paraplegia - adult onset; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
03 May 2019
Hereditary spastic paraplegia v1.203
TFG
Louise Daugherty reviewed gene: TFG: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
02 May 2019
Hereditary spastic paraplegia v1.203
TFG
Louise Daugherty Classified gene: TFG as Amber List (moderate evidence)
02 May 2019
Hereditary spastic paraplegia v1.203
TFG
Louise Daugherty Gene: tfg has been classified as Amber List (Moderate Evidence).
27 Nov 2018
Hereditary spastic paraplegia v1.71
TFG
Chris Buxton reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 23479643, 27492651, 27601211; Phenotypes: spastic paraplegia, optic atrophy, neuropathy; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal