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Inherited non-medullary thyroid cancer v1.7 | SEC23B | Arina Puzriakova Classified gene: SEC23B as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer v1.7 | SEC23B |
Arina Puzriakova Added comment: Comment on list classification: There is limited evidence linking this gene with Cowden syndrome (monoallelic variants). Only one family has been reported to date (PMID:26522472). The other variant identified in 2 unrelated women discussed in previous reviews, has since been reclassified as a VUS. This gene:disease association is provisional in OMIM, 'limited' disease confidence category in G2P and is not listed in ClinGen (whereas CDAII is). On this basis, downgrading the rating of this gene from Green to Red. |
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Inherited non-medullary thyroid cancer v1.7 | SEC23B | Arina Puzriakova Gene: sec23b has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer v1.6 | SEC23B | Arina Puzriakova Phenotypes for gene: SEC23B were changed from Cowden syndrome 7 616858 to Cowden syndrome 7, OMIM:616858 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer | SEC23B | Sarah Leigh marked SEC23B as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer | SEC23B | Sarah Leigh commented on SEC23B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer | SEC23B | Sarah Leigh classified SEC23B as green | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited non-medullary thyroid cancer | SEC23B | Emma Woodward reviewed SEC23B |