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| Childhood solid tumours v4.14 | CDKN2A | Arina Puzriakova Classified gene: CDKN2A as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Childhood solid tumours v4.14 | CDKN2A |
Arina Puzriakova Added comment: Comment on list classification: Well-established tumour suppressor gene associated with a variety of tumours, including cutaneous melanoma, pancreatic cancer and tumours of the nervous system such as astrocytomas. Onset is typically in adulthood but following specialist review, it was agreed that it is appropriate to include the CDKN2A gene on this panel. Rare paediatric cases are reported, as reviewed by Terri McVeigh (The Royal Marsden NHS). |
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| Childhood solid tumours v4.14 | CDKN2A | Arina Puzriakova Gene: cdkn2a has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Childhood solid tumours v4.13 | CDKN2A |
Arina Puzriakova Tag Q4_23_promote_green tag was added to gene: CDKN2A. Tag Q4_23_NHS_review tag was added to gene: CDKN2A. |
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| Childhood solid tumours v4.13 | CDKN2A | Arina Puzriakova Phenotypes for gene: CDKN2A were changed from cutaneous melanoma; pancreatic cancer; astrocytomas to {Melanoma, cutaneous malignant, 2}, OMIM:155601; {Melanoma and neural system tumor syndrome}, OMIM:155755; {Melanoma-pancreatic cancer syndrome}, OMIM:606719 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Childhood solid tumours v4.9 | CDKN2A |
Terri McVeigh gene: CDKN2A was added gene: CDKN2A was added to Childhood solid tumours. Sources: Expert Review,Literature Mode of inheritance for gene: CDKN2A was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CDKN2A were set to 24451801; 30207590 Phenotypes for gene: CDKN2A were set to cutaneous melanoma; pancreatic cancer; astrocytomas Penetrance for gene: CDKN2A were set to Incomplete Review for gene: CDKN2A was set to GREEN Added comment: Discussed at UKCGG/cancer leads meeting 06/07/2023 - agreed reasonable to include on panel Sources: Expert Review, Literature |
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