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16 Mar 2022	Intellectual disability - microarray and sequencing v3.1520	ISCA-37468-Loss	Arina Puzriakova commented on Region: ISCA-37468-Loss
16 Mar 2022	Intellectual disability - microarray and sequencing v3.1520	ISCA-37468-Loss	Arina Puzriakova Required Overlap Percentage for ISCA-37468-Loss was changed from 80 to 60.
09 Apr 2019	Intellectual disability - microarray and sequencing v2.800	ISCA-37468-Loss	Louise Daugherty Mode of inheritance for Region: ISCA-37468-Loss was changed from X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
09 Apr 2019	Intellectual disability - microarray and sequencing v2.799	ISCA-37468-Loss	Louise Daugherty Mode of inheritance for Region: ISCA-37468-Loss was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
07 Sep 2018	Intellectual disability - microarray and sequencing v2.398	ISCA-37468-Loss	Louise Daugherty Region: ISCA-37468-Loss was added Region: ISCA-37468-Loss was added to Intellectual disability. Sources: ClinGen,Expert Review Green Mode of inheritance for Region: ISCA-37468-Loss was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for Region: ISCA-37468-Loss were set to 20485326; 22365943; 23414621 Phenotypes for Region: ISCA-37468-Loss were set to episodes of sudden loss of muscle tone; severe intellectual disability; exiting behavior; short stature; eleveated serotonin levels; autistic features; lip-smacking; hypotonia; stereotypical hand movements