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Date	Panel	Item	Activity
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12 Oct 2020	Intellectual disability - microarray and sequencing v3.426	LAS1L	Ivone Leong changed review comment from: Comment on list classification: Based on the expert reviews and available evidence, this gene has been promoted from Red to Amber. As the ID severity in the second case in (PMID: 25644381) is unknown and the variant in 1 case reported by (PMID: 26358559) is predicted to be benign. Until there is further evidence this gene has been given an Amber rating.; to: Comment on list classification: Based on the expert reviews and available evidence, this gene has been promoted from Red to Amber. This gene is listed in OMIM and Gene2Phenotype with a relevant phenotype. In Gene2Phenotype it has been classified as probable course for the phenotype. As the ID severity in the second case in (PMID: 25644381) is unknown and the variant in 1 case reported by (PMID: 26358559) is predicted to be benign. Until there is further evidence this gene has been given an Amber rating.
12 Oct 2020	Intellectual disability - microarray and sequencing v3.426	LAS1L	Ivone Leong Classified gene: LAS1L as Amber List (moderate evidence)
12 Oct 2020	Intellectual disability - microarray and sequencing v3.426	LAS1L	Ivone Leong Added comment: Comment on list classification: Based on the expert reviews and available evidence, this gene has been promoted from Red to Amber. As the ID severity in the second case in (PMID: 25644381) is unknown and the variant in 1 case reported by (PMID: 26358559) is predicted to be benign. Until there is further evidence this gene has been given an Amber rating.
12 Oct 2020	Intellectual disability - microarray and sequencing v3.426	LAS1L	Ivone Leong Gene: las1l has been classified as Amber List (Moderate Evidence).
12 Oct 2020	Intellectual disability - microarray and sequencing v3.425	LAS1L	Ivone Leong Tag watchlist tag was added to gene: LAS1L.
08 Feb 2020	Intellectual disability - microarray and sequencing v3.0	LAS1L	Zornitza Stark reviewed gene: LAS1L: Rating: GREEN; Mode of pathogenicity: None; Publications: 25644381, 25644381; Phenotypes: Wilson-Turner syndrome, MIM# 309585; Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females; Current diagnostic: yes
29 Sep 2018	Intellectual disability - microarray and sequencing v2.468	LAS1L	Louise Daugherty Source Victorian Clinical Genetics Services was added to LAS1L.