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Date	Panel	Item	Activity
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30 Jan 2019	Intellectual disability - microarray and sequencing v2.619	MED23	Louise Daugherty Classified gene: MED23 as Green List (high evidence)
30 Jan 2019	Intellectual disability - microarray and sequencing v2.619	MED23	Louise Daugherty Added comment: Comment on list classification: Removed Watchlist tag. Changed from Amber to Green. Appropriate phenotype, sufficient cases, and external review comment all support gene-disease association
30 Jan 2019	Intellectual disability - microarray and sequencing v2.619	MED23	Louise Daugherty Gene: med23 has been classified as Green List (High Evidence).
30 Jan 2019	Intellectual disability - microarray and sequencing v2.618	MED23	Louise Daugherty Tag watchlist was removed from gene: MED23.
30 Jan 2019	Intellectual disability - microarray and sequencing v2.618	MED23	Louise Daugherty Added comment: Comment on publications: Added publications suggested from external expert review to support upgrading of the gene to Green
30 Jan 2019	Intellectual disability - microarray and sequencing v2.618	MED23	Louise Daugherty Publications for gene: MED23 were set to 21868677; 25845469; 25527630; 22129135
17 Dec 2018	Intellectual disability - microarray and sequencing v2.587	MED23	Konstantinos Varvagiannis reviewed gene: MED23: Rating: GREEN; Mode of pathogenicity: None; Publications: 21868677, 25845469, 27311965; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
17 Dec 2018	Intellectual disability - microarray and sequencing v2.587	MED23	Konstantinos Varvagiannis Deleted their review
17 Dec 2018	Intellectual disability - microarray and sequencing v2.587	MED23	Konstantinos Varvagiannis reviewed gene: MED23: Rating: GREEN; Mode of pathogenicity: None; Publications: 21868677, 25845469, 27311965; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
29 Sep 2018	Intellectual disability - microarray and sequencing v2.490	MED23	Louise Daugherty Classified gene: MED23 as Amber List (moderate evidence)
29 Sep 2018	Intellectual disability - microarray and sequencing v2.490	MED23	Louise Daugherty Added comment: Comment on list classification: Changed rating of gene from Red to Amber. This gene was rated as Amber in v2.467 and incorrectly automatically demoted to Red in v2.468. This was due to a defect in the automatic PanelApp uploading tool where a reference gene list was added as a new Source (Victorian Clinical Genetics Services), and under certain conditions associated to previous sources listed, resulted in the rating of the gene being automatically changed when it should not have been.
29 Sep 2018	Intellectual disability - microarray and sequencing v2.490	MED23	Louise Daugherty Gene: med23 has been classified as Amber List (Moderate Evidence).
29 Sep 2018	Intellectual disability - microarray and sequencing v2.468	MED23	Louise Daugherty Source Victorian Clinical Genetics Services was added to MED23.