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Neonatal diabetes v4.6 ONECUT1 Eleanor Williams Tag gene-checked tag was added to gene: ONECUT1.
Neonatal diabetes v4.6 ONECUT1 Achchuthan Shanmugasundram Tag to_be_confirmed_NHSE was removed from gene: ONECUT1.
Neonatal diabetes v4.6 ONECUT1 Sarah Leigh reviewed gene: ONECUT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Neonatal diabetes v4.5 ONECUT1 Achchuthan Shanmugasundram Source NHS GMS was added to ONECUT1.
Source Expert Review Green was added to ONECUT1.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Neonatal diabetes v4.4 ONECUT1 Achchuthan Shanmugasundram Tag Q3_22_rating was removed from gene: ONECUT1.
Tag Q3_22_NHS_review was removed from gene: ONECUT1.
Tag Q3_22_expert_review was removed from gene: ONECUT1.
Neonatal diabetes v3.3 ONECUT1 Arina Puzriakova Tag to_be_confirmed_NHSE tag was added to gene: ONECUT1.
Neonatal diabetes v3.3 ONECUT1 Arina Puzriakova commented on gene: ONECUT1
Neonatal diabetes v2.57 ONECUT1 Eleanor Williams Tag Q3_21_NHS_review was removed from gene: ONECUT1.
Tag Q3_21_expert_review was removed from gene: ONECUT1.
Tag Q3_22_NHS_review tag was added to gene: ONECUT1.
Tag Q3_22_expert_review tag was added to gene: ONECUT1.
Neonatal diabetes v2.57 ONECUT1 Eleanor Williams Tag Q3_21_NHS_review tag was added to gene: ONECUT1.
Tag Q3_21_expert_review tag was added to gene: ONECUT1.
Tag Q3_22_rating tag was added to gene: ONECUT1.
Neonatal diabetes v2.57 ONECUT1 Eleanor Williams Classified gene: ONECUT1 as Amber List (moderate evidence)
Neonatal diabetes v2.57 ONECUT1 Eleanor Williams Added comment: Comment on list classification: Promoting to amber, but with a recommendation for green rating following GMS expert review as to whether the age of onset of the cases indicates this gene-disease association is suitable for this panel. In 1 case the age of onset was 1 day old, in the other 14 months. The age of onset in the 3rd case is not known.
Neonatal diabetes v2.57 ONECUT1 Eleanor Williams Gene: onecut1 has been classified as Amber List (Moderate Evidence).
Neonatal diabetes v2.56 ONECUT1 Eleanor Williams Phenotypes for gene: ONECUT1 were changed from to ONECUT1-associated neonatal diabetes; neonatal diabetes mellitus, MONDO:0016391
Neonatal diabetes v2.55 ONECUT1 Eleanor Williams Publications for gene: ONECUT1 were set to
Neonatal diabetes v2.54 ONECUT1 Eleanor Williams Mode of inheritance for gene: ONECUT1 was changed from to BIALLELIC, autosomal or pseudoautosomal
Neonatal diabetes v2.53 ONECUT1 Eleanor Williams commented on gene: ONECUT1: Not associated with a phenotype in OMIM but is associated with ONECUT1-associated neonatal diabetes (strong) in Gene2Phenotype.

As reported by the reviewer Philippi et al 2021 report two unrelated (French and Turkish) patients from consanguineous families with homozgyous variants in OMECUT1 (1 nonsense, 1 missense) and a phenotype characterised by characterized by intrauterine growth retardation, pancreas hypoplasia and gallbladder agenesis/hypoplasia. Diabetes onset was at 1 day and 14 months in the two children respectively. Studies of the heterozygous carriers suggests that they are part of a distinctive subgroup of diabetic patients with early-onset, non-autoimmune diabetes, who respond well to diabetes treatment.

Note the eligibility criteria for this panel indicates that patients should be diagnosed with diabetes at less than 9 months of age.
Neonatal diabetes v2.40 ONECUT1 Eleanor Williams reviewed gene: ONECUT1: Rating: ; Mode of pathogenicity: ; Publications: 34663987; Phenotypes: Neonatal diabetes, pancreatic agenesis; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Neonatal diabetes v2.39 ONECUT1 Eleanor Williams gene: ONECUT1 was added
gene: ONECUT1 was added to Diabetes - neonatal onset. Sources: Expert review
Mode of inheritance for gene: ONECUT1 was set to