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Primary immunodeficiency or monogenic inflammatory bowel disease v2.166 ICOSLG Sarah Leigh Classified gene: ICOSLG as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.166 ICOSLG Sarah Leigh Gene: icoslg has been classified as Red List (Low Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.165 ICOSLG Sarah Leigh Classified gene: ICOSLG as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.165 ICOSLG Sarah Leigh Added comment: Comment on list classification: Not associated with phenotype in OMIM or in Gen2Phen. One homozygous variant reported in one case of Combined Immunodeficiency. Supportive functional evidence was presented. This variant in this French Canadian case has been reported twice in PMID 30498080 & 31532372.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.165 ICOSLG Sarah Leigh Gene: icoslg has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.164 ICOSLG Sarah Leigh Publications for gene: ICOSLG were set to 32086639; 32048120; 30498080; 31532372
Primary immunodeficiency or monogenic inflammatory bowel disease v2.163 ICOSLG Sarah Leigh Publications for gene: ICOSLG were set to 32086639; 32048120; 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.51 ICOSLG Zornitza Stark reviewed gene: ICOSLG: Rating: AMBER; Mode of pathogenicity: None; Publications: 31532372, 30498080; Phenotypes: Combined immunodeficiency, recurrent bacterial and viral infections, neutropaenia; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.36 ICOSLG Louise Daugherty edited their review of gene: ICOSLG: Added comment: Added publication referenced by IUIS december 2019 update; Changed rating: AMBER; Changed publications: 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.35 ICOSLG Louise Daugherty Publications for gene ICOSLG were updated from 32048120; 32086639 to 32086639; 32048120; 30498080
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 ICOSLG Louise Daugherty Source IUIS Classification December 2019 was added to ICOSLG.
Mode of inheritance for gene ICOSLG was changed from to BIALLELIC, autosomal or pseudoautosomal
Added phenotypes Recurrent bacterial and viral infections; Immunodeficiencies affecting cellular and humoral immunity for gene: ICOSLG
Publications for gene ICOSLG were updated from to 32048120; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Louise Daugherty classified ICOSLG as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Sophie Hambleton reviewed gene: ICOSLG
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Louise Daugherty classified ICOSLG as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease ICOSLG Louise Daugherty Added gene to panel