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Date	Panel	Item	Activity
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23 Jul 2019	Adult onset neurodegenerative disorder v1.74	ALAS2	Louise Daugherty commented on gene: ALAS2: Review and rating submitted by Nick Beauchamp (Sheffield Diagnostic genetics Service), on behalf of Yorkshire and North East GLH for GMS Neurology specialist test group.
23 Jul 2019	Adult onset neurodegenerative disorder v1.72	ALAS2	Nick Beauchamp reviewed gene: ALAS2: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
23 Jul 2019	Adult onset neurodegenerative disorder v1.67	ALAS2	Louise Daugherty Source Yorkshire and North East GLH was added to ALAS2.
23 Apr 2019	Adult onset neurodegenerative disorder v1.7	ALAS2	Louise Daugherty reviewed gene: ALAS2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
23 Apr 2019	Adult onset neurodegenerative disorder v1.6	ALAS2	Anthony Dallosso reviewed gene: ALAS2: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
23 Apr 2019	Adult onset neurodegenerative disorder v1.5	ALAS2	Louise Daugherty Source NHS GMS was added to ALAS2.
23 Apr 2019	Adult onset neurodegenerative disorder v1.4	ALAS2	Louise Daugherty Source South West GLH was added to ALAS2.
18 Dec 2018	Adult onset neurodegenerative disorder v0.2	ALAS2	Rebecca Foulger gene: ALAS2 was added gene: ALAS2 was added to Neurodegenerative disorders - adult onset. Sources: Expert Review Red Mode of inheritance for gene: ALAS2 was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)