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20 Sep 2019	Adult onset neurodegenerative disorder v1.106	CASK	Louise Daugherty edited their review of gene: CASK: Added comment: As discussed with the GMS Neurology Specialist Test Group webex call 11th September 2019: The Specialist Test Group all agreed that there is only enough evidence to rate this gene Red; Changed rating: RED
20 Sep 2019	Adult onset neurodegenerative disorder v1.105	CASK	Louise Daugherty Source Expert Review Red was added to CASK. Rating Changed from Green List (high evidence) to Red List (low evidence)
02 Sep 2019	Adult onset neurodegenerative disorder v1.101	CASK	Louise Daugherty commented on gene: CASK: Review and rating from Tracy Lester (Oxford Medical Genetics Laboratories Oxford University Hospitals NHS Foundation Trust) on behalf of Wessex and West Midlands GLH for GMS Neurology specialist test group. All the green and amber, except for the genes with triplet repeats, were reviewed.
02 Sep 2019	Adult onset neurodegenerative disorder v1.100	CASK	Louise Daugherty Source Wessex and West Midlands GLH was added to CASK.
02 Sep 2019	Adult onset neurodegenerative disorder v1.99	CASK	Tracy Lester reviewed gene: CASK: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: FG syndrome 4, 300422, Mental retardation and microcephaly with pontine and cerebellar hypoplasia, 300749; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
23 Jul 2019	Adult onset neurodegenerative disorder v1.74	CASK	Louise Daugherty commented on gene: CASK: Review and rating submitted by Nick Beauchamp (Sheffield Diagnostic genetics Service), on behalf of Yorkshire and North East GLH for GMS Neurology specialist test group.
23 Jul 2019	Adult onset neurodegenerative disorder v1.72	CASK	Nick Beauchamp reviewed gene: CASK: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: FG syndrome 4, 300422, Mental retardation and microcephaly with pontine and cerebellar hypoplasia, 300749; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
23 Jul 2019	Adult onset neurodegenerative disorder v1.67	CASK	Louise Daugherty Source Yorkshire and North East GLH was added to CASK.
23 Apr 2019	Adult onset neurodegenerative disorder v1.11	CASK	Louise Daugherty reviewed gene: CASK: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
23 Apr 2019	Adult onset neurodegenerative disorder v1.10	CASK	James Polke reviewed gene: CASK: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
23 Apr 2019	Adult onset neurodegenerative disorder v1.9	CASK	Louise Daugherty Source NHS GMS was added to CASK.
23 Apr 2019	Adult onset neurodegenerative disorder v1.8	CASK	Louise Daugherty Source London North GLH was added to CASK.
09 Jan 2019	Adult onset neurodegenerative disorder v0.144	CASK	Louise Daugherty Phenotypes for gene: CASK were changed from to FG syndrome 4, 300422; Mental retardation and microcephaly with pontine and cerebellar hypoplasia, 300749
18 Dec 2018	Adult onset neurodegenerative disorder v0.2	CASK	Rebecca Foulger gene: CASK was added gene: CASK was added to Neurodegenerative disorders - adult onset. Sources: Expert Review Green Mode of inheritance for gene: CASK was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)