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Date	Panel	Item	Activity
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10 Mar 2022	Paediatric disorders - additional genes v1.96	ANOS1	Arina Puzriakova Tag for-review was removed from gene: ANOS1.
10 Mar 2022	Paediatric disorders - additional genes v1.96	ANOS1	Sarah Leigh commented on gene: ANOS1
10 Mar 2022	Paediatric disorders - additional genes v1.95	ANOS1	Arina Puzriakova Source Expert Review Green was added to ANOS1. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
19 Oct 2020	Paediatric disorders - additional genes v1.56	ANOS1	Arina Puzriakova Classified gene: ANOS1 as Amber List (moderate evidence)
19 Oct 2020	Paediatric disorders - additional genes v1.56	ANOS1	Arina Puzriakova Added comment: Comment on list classification: Changed rating to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update.
19 Oct 2020	Paediatric disorders - additional genes v1.56	ANOS1	Arina Puzriakova Gene: anos1 has been classified as Amber List (Moderate Evidence).
14 May 2020	Paediatric disorders - additional genes v1.31	ANOS1	Rebecca Foulger Classified gene: ANOS1 as Green List (high evidence)
14 May 2020	Paediatric disorders - additional genes v1.31	ANOS1	Rebecca Foulger Gene: anos1 has been classified as Green List (High Evidence).
14 May 2020	Paediatric disorders - additional genes v1.30	ANOS1	Rebecca Foulger Classified gene: ANOS1 as Amber List (moderate evidence)
14 May 2020	Paediatric disorders - additional genes v1.30	ANOS1	Rebecca Foulger Added comment: Comment on list classification: Updated rating from Amber to Green, awaiting GLH review. Sufficient cases to support Kallman syndrome association, which can present with phenotypes beyond renal, some of which could be detected at birth.
14 May 2020	Paediatric disorders - additional genes v1.30	ANOS1	Rebecca Foulger Gene: anos1 has been classified as Amber List (Moderate Evidence).
14 May 2020	Paediatric disorders - additional genes v1.29	ANOS1	Rebecca Foulger commented on gene: ANOS1: PMID:16423815. Trarbach et al 2005 report 12 Kallmann syndrome (KS) patients. Two ANOS1 variants (referred to as KAL-1 gene) were found in 2 KS patients (Arg191X, and del1956C leading to a premature stop codon at 617). A patient with a KAL-1 microdeletion was also reported. Renal agenesis and bimanual synkinesis were observed in these cases.
14 May 2020	Paediatric disorders - additional genes v1.29	ANOS1	Rebecca Foulger Publications for gene: ANOS1 were set to 1518845
14 May 2020	Paediatric disorders - additional genes v1.28	ANOS1	Rebecca Foulger Phenotypes for gene: ANOS1 were changed from CAKUT; Kallman syndrome; Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1) to CAKUT; Kallman syndrome; Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1), 308700
12 May 2020	Paediatric disorders - additional genes v1.22	ANOS1	Rebecca Foulger changed review comment from: Added 'for-review' tag: Requires GLH review as to whether CAKUT phenotype is sufficient for inclusion on Paediatric disorders panel.; to: Added 'for-review' tag: Requires GLH review as to whether phenotype is sufficient for inclusion on Paediatric disorders panel.
12 May 2020	Paediatric disorders - additional genes v1.22	ANOS1	Rebecca Foulger changed review comment from: Sufficient cases of variants in ANOS1 to support association with Kallmann syndrome (MIM:308700). KS phenotypes are present at birth and can include renal agenesis, and micropenis. Cases are often reported at puberty with lack of sexual development.; to: Sufficient cases of variants in ANOS1 to support association with Kallmann syndrome (MIM:308700). KS phenotypes are present at birth and can include renal agenesis, and micropenis. Cases are often reported at puberty with lack of sexual development.
12 May 2020	Paediatric disorders - additional genes v1.22	ANOS1	Rebecca Foulger Publications for gene: ANOS1 were set to
12 May 2020	Paediatric disorders - additional genes v1.21	ANOS1	Rebecca Foulger commented on gene: ANOS1: Sufficient cases of variants in ANOS1 to support association with Kallmann syndrome (MIM:308700). KS phenotypes are present at birth and can include renal agenesis, and micropenis. Cases are often reported at puberty with lack of sexual development.
12 May 2020	Paediatric disorders - additional genes v1.9	ANOS1	Rebecca Foulger Classified gene: ANOS1 as Amber List (moderate evidence)
12 May 2020	Paediatric disorders - additional genes v1.9	ANOS1	Rebecca Foulger Gene: anos1 has been classified as Amber List (Moderate Evidence).
12 May 2020	Paediatric disorders - additional genes v1.4	ANOS1	Rebecca Foulger Tag for-review tag was added to gene: ANOS1.
12 May 2020	Paediatric disorders - additional genes v1.4	ANOS1	Rebecca Foulger commented on gene: ANOS1: Added 'for-review' tag: Requires GLH review as to whether CAKUT phenotype is sufficient for inclusion on Paediatric disorders panel.
12 May 2020	Paediatric disorders - additional genes v1.4	ANOS1	Rebecca Foulger commented on gene: ANOS1
12 May 2020	Paediatric disorders - additional genes v1.3	ANOS1	Rebecca Foulger gene: ANOS1 was added gene: ANOS1 was added to Paediatric disorders - additional genes. Sources: Other,Expert Review Green Mode of inheritance for gene: ANOS1 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females Phenotypes for gene: ANOS1 were set to CAKUT; Kallman syndrome; Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1)