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RASopathies v1.81 RRAS Sarah Leigh Classified gene: RRAS as Green List (high evidence)
RASopathies v1.81 RRAS Sarah Leigh Gene: rras has been classified as Green List (High Evidence).
RASopathies v1.80 RRAS Sarah Leigh Tag Q2_24_promote_green was removed from gene: RRAS.
RASopathies v1.80 RRAS Sarah Leigh Tag Q2_24_promote_green tag was added to gene: RRAS.
RASopathies v1.80 RRAS Sarah Leigh Publications for gene: RRAS were set to 24705357
RASopathies v1.79 RRAS Sarah Leigh edited their review of gene: RRAS: Added comment: RRAS variants have not associated with a phenotype in OMIM or MONDO, but Gen2Phen lists a strong association between RRAS variants and RRAS-related atypical Noonan syndrome. Three germline RRAS variants have been reported (PMID: 24705357; 32815881; 34935735), associated with a RASopathy, which includes myelodysplastic syndrome and contributes to leukaemogenesis.; Changed rating: GREEN; Changed publications to: 24705357, 32815881, 34935735
RASopathies v1.79 RRAS Sarah Leigh Added comment: Comment on phenotypes: Phenotype from Gen2Phen
RASopathies v1.79 RRAS Sarah Leigh Phenotypes for gene: RRAS were changed from Noonan syndrome to RRAS-related atypical Noonan syndrome
RASopathies v1.72 RRAS2 Ivone Leong Publications for gene: RRAS2 were set to 31130282
RASopathies v1.71 RRAS2 Ivone Leong Phenotypes for gene: RRAS2 were changed from Noonan syndrome 12, OMIM #618624 to Noonan syndrome 12, 618624
RASopathies v1.61 RRAS Arina Puzriakova Classified gene: RRAS as Amber List (moderate evidence)
RASopathies v1.61 RRAS Arina Puzriakova Added comment: Comment on list classification: Rated Amber as additional cases required to validate the causal association with the phenotype.

Currently not associated with any phenotype in OMIM but a probable gene for Atypical Noonan Syndrome in G2P.
RASopathies v1.61 RRAS Arina Puzriakova Gene: rras has been classified as Amber List (Moderate Evidence).
RASopathies v1.60 RRAS2 Arina Puzriakova Mode of pathogenicity for gene: RRAS2 was changed from None to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
RASopathies v1.59 RRAS2 Arina Puzriakova Classified gene: RRAS2 as Green List (high evidence)
RASopathies v1.59 RRAS2 Arina Puzriakova Gene: rras2 has been classified as Green List (High Evidence).
RASopathies v1.58 RRAS2 Arina Puzriakova reviewed gene: RRAS2: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 31130282, 31130285; Phenotypes: Noonan syndrome 12, 618624; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
RASopathies v1.55 RRAS2 Zornitza Stark gene: RRAS2 was added
gene: RRAS2 was added to RASopathies. Sources: Expert list
Mode of inheritance for gene: RRAS2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: RRAS2 were set to 31130282
Phenotypes for gene: RRAS2 were set to Noonan syndrome 12, OMIM #618624
Review for gene: RRAS2 was set to GREEN
gene: RRAS2 was marked as current diagnostic
Added comment: Six unrelated families reported
Sources: Expert list
RASopathies v1.55 RRAS Zornitza Stark gene: RRAS was added
gene: RRAS was added to RASopathies. Sources: Expert list
Mode of inheritance for gene: RRAS was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: RRAS were set to 24705357
Phenotypes for gene: RRAS were set to Noonan syndrome
Review for gene: RRAS was set to AMBER
Added comment: Two individuals reported. One de novo variant, the inheritance of the other variant uncertain. Some supportive functional data. Rated as LIMITED by ClinGen.
Sources: Expert list