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31 Jan 2023	Pituitary hormone deficiency v2.106	IGSF1	Catherine Snow Tag Q3_22_MOI was removed from gene: IGSF1. Tag Q3_22_NHS_review was removed from gene: IGSF1.
31 Jan 2023	Pituitary hormone deficiency v2.106	IGSF1	Catherine Snow commented on gene: IGSF1
31 Jan 2023	Pituitary hormone deficiency v2.105	IGSF1	Catherine Snow Source NHS GMS was added to IGSF1. Mode of inheritance for gene IGSF1 was changed from X-LINKED: hemizygous mutation in males, biallelic mutations in females to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
17 Sep 2022	Pituitary hormone deficiency v2.50	IGSF1	Eleanor Williams Tag Q3_22_MOI tag was added to gene: IGSF1. Tag Q3_22_NHS_review tag was added to gene: IGSF1.
17 Sep 2022	Pituitary hormone deficiency v2.50	IGSF1	Eleanor Williams Added comment: Comment on mode of inheritance: Heterozygous female carriers may show a phenotype related to the pituitary gland. In PMID: 24108313 (Joustra et al 2013) they report 6 females were biochemically hypothyroid, and 2 were prolactin deficient. (hypothyroid is linked to decreased function of the pituitary gland and prolactin is produced in the pituitary gland). PMID: 30086211 (Roche et al 2018) also report a heterozygous female with central hypothyroidism. Therefore it is proposed to change the mode of inheritance to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease
17 Sep 2022	Pituitary hormone deficiency v2.50	IGSF1	Eleanor Williams Mode of inheritance for gene: IGSF1 was changed from X-LINKED: hemizygous mutation in males, biallelic mutations in females to X-LINKED: hemizygous mutation in males, biallelic mutations in females
17 Sep 2022	Pituitary hormone deficiency v2.49	IGSF1	Eleanor Williams edited their review of gene: IGSF1: Changed mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
17 Sep 2022	Pituitary hormone deficiency v2.49	IGSF1	Eleanor Williams edited their review of gene: IGSF1: Changed mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females
17 Sep 2022	Pituitary hormone deficiency v2.49	IGSF1	Eleanor Williams Phenotypes for gene: IGSF1 were changed from Hypothyroidism, central, and testicular enlargement (300888) to Hypothyroidism, central, and testicular enlargement, OMIM:300888
14 Sep 2022	Pituitary hormone deficiency v2.15	IGSF1	Eleanor Williams reviewed gene: IGSF1: Rating: ; Mode of pathogenicity: ; Publications: 23143598; Phenotypes: MACRO-ORCHIDISM, TSH, GH AND PROLACTIN DEFICIENCIES,; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
29 Jan 2019	Pituitary hormone deficiency v0.71	IGSF1	Ivone Leong commented on gene: IGSF1: As discussed in the GMS Endocrinology Specialist Test Group webex call 28th Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
08 Jan 2019	Pituitary hormone deficiency v0.65	IGSF1	Ivone Leong Marked gene: IGSF1 as ready
08 Jan 2019	Pituitary hormone deficiency v0.65	IGSF1	Ivone Leong Gene: igsf1 has been classified as Green List (High Evidence).
13 Dec 2018	Pituitary hormone deficiency v0.45	IGSF1	Ivone Leong Classified gene: IGSF1 as Green List (high evidence)
13 Dec 2018	Pituitary hormone deficiency v0.45	IGSF1	Ivone Leong Added comment: Comment on list classification: Promoted from red to green. IGSF1 is confirmed to be associated with Hypothyroidism, central, and testicular enlargement in OMIM and Gene2Phenotypes. It is a green gene in the Congenital hypothyroidism panel (Version 1.4). There are >3 unrelated cases of patients with variants in IGSF1 who have pituitary hormone deficiency.
13 Dec 2018	Pituitary hormone deficiency v0.45	IGSF1	Ivone Leong Gene: igsf1 has been classified as Green List (High Evidence).
13 Dec 2018	Pituitary hormone deficiency v0.44	IGSF1	Ivone Leong Publications for gene: IGSF1 were set to
07 Dec 2018	Pituitary hormone deficiency v0.5	IGSF1	Ivone Leong gene: IGSF1 was added gene: IGSF1 was added to Pituitary hormone deficiency. Sources: Radboud University Medical Center Mode of inheritance for gene: IGSF1 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females Phenotypes for gene: IGSF1 were set to Hypothyroidism, central, and testicular enlargement (300888)