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Cytopenia - NOT Fanconi anaemia v0.135 FYB1 Louise Daugherty edited their review of gene: FYB1: Added comment: Gene reviewed due to Haematology Specialist Test Group considering the inclusion of relevant neutropenia thrombocytopenia genes. The Specialist Test Group 21st October 2019 (consisting of 4 centres: WWMGLH, NWGLH, YNEGLH, LSGLH) all agreed that there is enough evidence to rate this gene Green. Additional comments from Haematology Specialist Test Group (Copy of Extra genes R91_consensus_v2.xlsx) 21st October 2019. Wessex and West Midlands GLH: Thrombocytopenia 3; North West GLH: no comment submitted; Yorkshire and North East GLH: Rare (2cases); London South GLH: no comment submitted.; Changed rating: GREEN
Cytopenia - NOT Fanconi anaemia v0.134 FYB1 Louise Daugherty Source Expert review Green was added to FYB1.
Cytopenia - NOT Fanconi anaemia v0.132 FYB1 Louise Daugherty Source Wessex and West Midlands GLH was added to FYB1.
Cytopenia - NOT Fanconi anaemia v0.62 FYB1 Louise Daugherty Classified gene: FYB1 as Green List (high evidence)
Cytopenia - NOT Fanconi anaemia v0.62 FYB1 Louise Daugherty Added comment: Comment on list classification: As discussed with the GMS Haematology Specialist Test Group at workshop 2nd July 2019. All agreed that there is enough evidence to rate this gene Green.
Cytopenia - NOT Fanconi anaemia v0.62 FYB1 Louise Daugherty Gene: fyb1 has been classified as Green List (High Evidence).
Cytopenia - NOT Fanconi anaemia v0.61 FYB1 Louise Daugherty commented on gene: FYB1: Discrepant reviews for FYB1. Rated as Green by YNEGLH, LSGLH - Amber rating by NWGLH, no review by WWMGLH. To be discussed at July workshop to agree rating.
Cytopenia - NOT Fanconi anaemia v0.53 FYB1 Louise Daugherty Source London South GLH was added to FYB1.
Cytopenia - NOT Fanconi anaemia v0.52 FYB1 Louise Daugherty commented on gene: FYB1: New review/rating by Frances Smith, Viapath Kings College Hospital (Curation_Template_GMS_Haem_FS_updated_reviews_20190425.xlsx) on behalf of London South GLH for the GMS Haematology specialist test group. Gene rated as Green.
Cytopenia - NOT Fanconi anaemia v0.51 FYB1 Frances Smith reviewed gene: FYB1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Cytopenia - NOT Fanconi anaemia v0.31 FYB1 Louise Daugherty commented on gene: FYB1: Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: FYB1; Suggested initial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Phenotypes: 273900 Thrombocytopenia 3; PMID(s): 25876182; 25516138
Cytopenia - NOT Fanconi anaemia v0.30 FYB1 Steve Keeney reviewed gene: FYB1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: Thrombocytopenia 3, 273900; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia v0.29 FYB1 Louise Daugherty Added phenotypes Thrombocytopenia 3, 273900 for gene: FYB1
Publications for gene FYB1 were changed from to 25516138; 25876182
Cytopenia - NOT Fanconi anaemia v0.27 FYB1 Louise Daugherty Source North West GLH was added to FYB1.
Rating Changed from Green List (high evidence) to Green List (high evidence)
Cytopenia - NOT Fanconi anaemia v0.22 FYB1 Louise Daugherty Mode of inheritance for gene: FYB1 was changed from to BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia v0.21 FYB1 Louise Daugherty Classified gene: FYB1 as Green List (high evidence)
Cytopenia - NOT Fanconi anaemia v0.21 FYB1 Louise Daugherty Gene: fyb1 has been classified as Green List (High Evidence).
Cytopenia - NOT Fanconi anaemia v0.18 FYB1 Louise Daugherty reviewed gene: FYB1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Cytopenia - NOT Fanconi anaemia v0.17 FYB1 Mandy nesbitt reviewed gene: FYB1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: 273900 Thrombocytopenia 3; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia v0.16 FYB1 Louise Daugherty Added phenotypes 273900 Thrombocytopenia 3 for gene: FYB1
Cytopenia - NOT Fanconi anaemia v0.15 FYB1 Louise Daugherty Source NHS GMS was added to FYB1.
Cytopenia - NOT Fanconi anaemia v0.14 FYB1 Louise Daugherty gene: FYB1 was added
gene: FYB1 was added to Cytopenia - NOT Fanconi anaemia. Sources: Yorkshire and North East GLH
Mode of inheritance for gene: FYB1 was set to