| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Breast cancer pertinent cancer susceptibility v2.12 | CDH1 | Achchuthan Shanmugasundram Classified gene: CDH1 as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.12 | CDH1 | Achchuthan Shanmugasundram Gene: cdh1 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.11 | CDH1 | Achchuthan Shanmugasundram Classified gene: CDH1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.11 | CDH1 | Achchuthan Shanmugasundram Gene: cdh1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.10 | CDH1 | Achchuthan Shanmugasundram Classified gene: CDH1 as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.10 | CDH1 | Achchuthan Shanmugasundram Gene: cdh1 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.9 | CDH1 |
Achchuthan Shanmugasundram Tag Q3_23_promote_green was removed from gene: CDH1. Tag Q3_23_expert_review was removed from gene: CDH1. |
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| Breast cancer pertinent cancer susceptibility v2.9 | CDH1 | Arina Puzriakova edited their review of gene: CDH1: Added comment: After NHS Genomic Medicine Service consideration, this gene has not been made Green and has been rated as Red. Additional comments from reviewing GLHs: 'There is a well established association of this gene withpredisposition to lobular breast cancer, but it presents huge problems when it is identified outside the context of a relevant family history. The UK Cancer genetics community do not want to add this gene to any general breast cancer susceptibility panels hence are extremely reluctant to test this gene outside of the already existing R215 criteria'; Changed rating: RED; Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.5 | CDH1 | Arina Puzriakova Publications for gene: CDH1 were set to 36436516 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.4 | CDH1 | Arina Puzriakova Phenotypes for gene: CDH1 were changed from Lobular breast cancer to Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate, OMIM:137215 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.3 | CDH1 |
Arina Puzriakova Tag Q3_23_promote_green tag was added to gene: CDH1. Tag Q3_23_expert_review tag was added to gene: CDH1. |
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| Breast cancer pertinent cancer susceptibility v2.3 | CDH1 | Arina Puzriakova Classified gene: CDH1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.3 | CDH1 |
Arina Puzriakova Added comment: Comment on list classification: New gene added to this panel by Lauma Freimane. Germline heterozygous variants have been found in diffuse gastric and lobular breast cancer syndrome. Patients may develop lobular breast cancer only or lobular breast cancer with gastric cancer. Lobular carcinoma of the breast has been reported in up to 60% of female carriers. Overall there is sufficient evidence to classify this as a breast cancer susceptibility gene. However, it should be noted that this gene is already covered by a targeted panel, R215 CDH1-related cancer syndrome. Will leave the decision with the GMS expert group as to whether this phenotype should also be covered by this panel. |
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| Breast cancer pertinent cancer susceptibility v2.3 | CDH1 | Arina Puzriakova Gene: cdh1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Breast cancer pertinent cancer susceptibility v2.1 | CDH1 |
Lauma Freimane gene: CDH1 was added gene: CDH1 was added to Breast cancer pertinent cancer susceptibility. Sources: Literature Mode of inheritance for gene: CDH1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CDH1 were set to 36436516 Phenotypes for gene: CDH1 were set to Lobular breast cancer Review for gene: CDH1 was set to GREEN Added comment: Sources: Literature |
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