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21 May 2019	Childhood onset hereditary spastic paraplegia v1.166	AMPD2	Louise Daugherty commented on gene: AMPD2: Amber gene with Green GLH rating, Gene discussed in view of discrepant rating(s) from GLH(s). Amber rating agreed at the GMS Neurology Specialist Test Group Webex on 17th May 2019.
13 May 2019	Childhood onset hereditary spastic paraplegia v1.156	AMPD2	Louise Daugherty Phenotypes for gene: AMPD2 were changed from Hereditary Spastic Paraplegia?; Pontocerebellar hypolplasia (biallelic) to ?Spastic paraplegia 63, 615686, AR; Pontocerebellar hypoplasia, type 9, 615809, AR
13 May 2019	Childhood onset hereditary spastic paraplegia v1.155	AMPD2	Louise Daugherty Publications for gene: AMPD2 were set to Novarino et al. (2014)
13 May 2019	Childhood onset hereditary spastic paraplegia v1.154	AMPD2	Louise Daugherty Deleted their comment
13 May 2019	Childhood onset hereditary spastic paraplegia v1.75	AMPD2	Louise Daugherty Source Yorkshire and North East GLH was added to AMPD2.
09 May 2019	Childhood onset hereditary spastic paraplegia v1.74	AMPD2	Louise Daugherty commented on gene: AMPD2: Rating and review submitted on behalf of James Polke (Neurogenetics Laboratory,Institute of Neurology, London), on behalf of London North GLH for GMS Neurology specialist test group.
03 May 2019	Childhood onset hereditary spastic paraplegia v1.73	AMPD2	Nick Beauchamp reviewed gene: AMPD2: Rating: AMBER; Mode of pathogenicity: None; Publications: 24482476, 27159321; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
02 May 2019	Childhood onset hereditary spastic paraplegia v1.50	AMPD2	Louise Daugherty edited their review of gene: AMPD2: Changed rating: AMBER
02 May 2019	Childhood onset hereditary spastic paraplegia v1.50	AMPD2	Louise Daugherty edited their review of gene: AMPD2: Added comment: Red rating on Hereditary spastic paraplegia panel 1.198 nonsense variant in single family in exome study. Low evidence Chris Buxton (North Bristol NHS Trust), 27 Nov 2018 Comment when marking as ready: Single family only - more evidence required emma baple (Genomics England Curator), 8 Feb 2016; Changed rating: RED
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.48	AMPD2	Louise Daugherty reviewed gene: AMPD2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.9	AMPD2	Louise Daugherty Classified gene: AMPD2 as Amber List (moderate evidence)
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.9	AMPD2	Louise Daugherty Gene: ampd2 has been classified as Amber List (Moderate Evidence).
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.6	AMPD2	James Polke reviewed gene: AMPD2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ?Spastic paraplegia 63, 615686, AR, Pontocerebellar hypoplasia, type 9, 615809, AR ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.5	AMPD2	Louise Daugherty Source NHS GMS was added to AMPD2.
28 Apr 2019	Childhood onset hereditary spastic paraplegia v1.4	AMPD2	Louise Daugherty Source London North GLH was added to AMPD2.
03 Apr 2019	Childhood onset hereditary spastic paraplegia v1.3	AMPD2	Louise Daugherty Added phenotypes Hereditary Spastic Paraplegia?; Pontocerebellar hypolplasia (biallelic) for gene: AMPD2
19 Dec 2018	Childhood onset hereditary spastic paraplegia v0.6	AMPD2	Sarah Leigh gene: AMPD2 was added gene: AMPD2 was added to Hereditary spastic paraplegia - childhood onset. Sources: Expert list,Expert Review Red Mode of inheritance for gene: AMPD2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: AMPD2 were set to Novarino et al. (2014) Phenotypes for gene: AMPD2 were set to Pontocerebellar hypolplasia (biallelic); Hereditary Spastic Paraplegia?