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Date	Panel	Item	Activity
Filter activities 19 actions
14 Mar 2022	Childhood onset hereditary spastic paraplegia v2.130	ARL6IP1	Ivone Leong Tag Q2_21_rating was removed from gene: ARL6IP1.
14 Mar 2022	Childhood onset hereditary spastic paraplegia v2.130	ARL6IP1	Sarah Leigh commented on gene: ARL6IP1
14 Mar 2022	Childhood onset hereditary spastic paraplegia v2.129	ARL6IP1	Ivone Leong Source Expert Review Green was added to ARL6IP1. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.44	ARL6IP1	Eleanor Williams Phenotypes for gene: ARL6IP1 were changed from Spastic paraplegia to Spastic paraplegia 61, autosomal recessive, OMIM:615685; hereditary spastic paraplegia 61, MONDO:0014304
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.43	ARL6IP1	Eleanor Williams Publications for gene: ARL6IP1 were set to Novarino et al. (2014); 24482476; 28471035
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.42	ARL6IP1	Eleanor Williams Classified gene: ARL6IP1 as Amber List (moderate evidence)
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.42	ARL6IP1	Eleanor Williams Added comment: Comment on list classification: Leaving rating as amber but with recommendation for promotion to green at the next review. 4 cases reported with 3 different variants.
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.42	ARL6IP1	Eleanor Williams Gene: arl6ip1 has been classified as Amber List (Moderate Evidence).
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.41	ARL6IP1	Eleanor Williams Tag Q2_21_rating tag was added to gene: ARL6IP1.
30 Jun 2021	Childhood onset hereditary spastic paraplegia v2.41	ARL6IP1	Eleanor Williams reviewed gene: ARL6IP1: Rating: GREEN; Mode of pathogenicity: None; Publications: 24482476, 31272422, 30980493, 28471035; Phenotypes: Spastic paraplegia 61, autosomal recessive, OMIM:615685; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
16 Jun 2020	Childhood onset hereditary spastic paraplegia v2.12	ARL6IP1	Zornitza Stark reviewed gene: ARL6IP1: Rating: GREEN; Mode of pathogenicity: None; Publications: 24482476, 31272422, 30980493, 28471035; Phenotypes: Spastic paraplegia 61, autosomal recessive, MIM#615685; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
21 May 2019	Childhood onset hereditary spastic paraplegia v1.166	ARL6IP1	Louise Daugherty reviewed gene: ARL6IP1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
21 May 2019	Childhood onset hereditary spastic paraplegia v1.165	ARL6IP1	Louise Daugherty Source Expert Review Amber was added to ARL6IP1. Rating Changed from Red List (low evidence) to Amber List (moderate evidence)
13 May 2019	Childhood onset hereditary spastic paraplegia v1.94	ARL6IP1	Louise Daugherty Phenotypes for gene: ARL6IP1 were changed from to Spastic paraplegia
13 May 2019	Childhood onset hereditary spastic paraplegia v1.93	ARL6IP1	Louise Daugherty Publications for gene: ARL6IP1 were set to Novarino et al. (2014)
13 May 2019	Childhood onset hereditary spastic paraplegia v1.76	ARL6IP1	Louise Daugherty Source NHS GMS was added to ARL6IP1.
13 May 2019	Childhood onset hereditary spastic paraplegia v1.75	ARL6IP1	Louise Daugherty Source Yorkshire and North East GLH was added to ARL6IP1.
10 May 2019	Childhood onset hereditary spastic paraplegia v1.74	ARL6IP1	Nick Beauchamp reviewed gene: ARL6IP1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: 24482476, 28471035; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
19 Dec 2018	Childhood onset hereditary spastic paraplegia v0.6	ARL6IP1	Sarah Leigh gene: ARL6IP1 was added gene: ARL6IP1 was added to Hereditary spastic paraplegia - childhood onset. Sources: Expert list,Expert Review Red Mode of inheritance for gene: ARL6IP1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ARL6IP1 were set to Novarino et al. (2014)