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| Haematological malignancies cancer susceptibility v2.23 | IKZF1 | Arina Puzriakova Tag for-review was removed from gene: IKZF1. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.23 | IKZF1 | Arina Puzriakova commented on gene: IKZF1: The rating of this gene has been updated following NHS Genomic Medicine Service approval. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.22 | IKZF1 |
Arina Puzriakova Source Expert Review Green was added to IKZF1. Source NHS GMS was added to IKZF1. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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| Haematological malignancies cancer susceptibility v2.11 | IKZF1 | Arina Puzriakova edited their review of gene: IKZF1: Changed publications: 26981933, 28096536, 29889099, 29681510 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.11 | IKZF1 | Arina Puzriakova Publications for gene: IKZF1 were set to PMID: 29681510; PMID: 29889099; PMID: 27939403 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.10 | IKZF1 | Arina Puzriakova Classified gene: IKZF1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.10 | IKZF1 | Arina Puzriakova Added comment: Comment on list classification: New gene added by Kiran Tawana (Addenbrooke's Hospital, Cambridge). Several studies indicate that coding germline IKZF1 variants are a risk factor for genetic predisposition to ALL. Therefore, this gene may be promoted to Green at the next panel update following GMS review (added 'for-review' tag) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.10 | IKZF1 | Arina Puzriakova Gene: ikzf1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.9 | IKZF1 | Arina Puzriakova Tag for-review tag was added to gene: IKZF1. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.9 | IKZF1 | Arina Puzriakova reviewed gene: IKZF1: Rating: GREEN; Mode of pathogenicity: None; Publications: 26981933, 28096536, 29681510; Phenotypes: Acute lymphoblastic leukemia (ALL), Immunodeficiency, common variable, 13, OMIM:616873; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.9 | IKZF1 | Arina Puzriakova Phenotypes for gene: IKZF1 were changed from B-ALL; immunodeficiency, autoimmunity to Acute lymphoblastic leukaemia (ALL); Immunodeficiency, common variable, 13, OMIM:616873 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.5 | IKZF1 |
Kiran Tawana gene: IKZF1 was added gene: IKZF1 was added to Haematological malignancies cancer susceptibility. Sources: Literature Mode of inheritance for gene: IKZF1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: IKZF1 were set to PMID: 29681510; PMID: 29889099; PMID: 27939403 Phenotypes for gene: IKZF1 were set to B-ALL; immunodeficiency, autoimmunity Penetrance for gene: IKZF1 were set to unknown Review for gene: IKZF1 was set to GREEN Added comment: Sources: Literature |
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