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| Haematological malignancies cancer susceptibility v3.3 | RPS15 |
Arina Puzriakova Tag Q3_22_rating was removed from gene: RPS15. Tag Q3_22_expert_review was removed from gene: RPS15. |
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| Haematological malignancies cancer susceptibility v3.3 | RPS15 | Arina Puzriakova edited their review of gene: RPS15: Added comment: The rating of this gene has been updated to Red following NHS Genomic Medicine Service approval.; Changed rating: RED | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v3.2 | RPS15 |
Arina Puzriakova Source NHS GMS was added to RPS15. Source Expert Review Red was added to RPS15. Rating Changed from Green List (high evidence) to Red List (low evidence) |
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| Haematological malignancies cancer susceptibility v2.36 | RPS15 |
Arina Puzriakova commented on gene: RPS15: This gene has been flagged for GMS expert review as published evidence linking germline variants to haematological malignancies is limited, which may warrant a rating downgrade from Green, subject to review. RPS15 somatic variants are enriched within chronic lymphocytic leukemia, particularly in aggressive cases - however, the contribution of germline variants is not well-defined. |
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| Haematological malignancies cancer susceptibility v2.36 | RPS15 | Arina Puzriakova Tag somatic tag was added to gene: RPS15. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.36 | RPS15 |
Arina Puzriakova Tag Q3_22_rating tag was added to gene: RPS15. Tag Q3_22_expert_review tag was added to gene: RPS15. |
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| Haematological malignancies cancer susceptibility v2.36 | RPS15 | Arina Puzriakova Phenotypes for gene: RPS15 were changed from Class: BM failure syndrome (typ AR); Diamond Blackfan Anemia; MDS, AML; Osteosarcoma, soft tissue sarcomas to Diamond-Blackfan anemia; Chronic lymphocytic leukemia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.35 | RPS15 | Arina Puzriakova Publications for gene: RPS15 were set to 28297620 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.34 | RPS15 | Arina Puzriakova reviewed gene: RPS15: Rating: ; Mode of pathogenicity: None; Publications: 19061985, 26466571, 26675346, 30181176, 34251413; Phenotypes: Diamond-Blackfan anemia, Chronic lymphocytic leukemia; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.30 | RPS15 | Eleanor Williams Tag gene-checked tag was added to gene: RPS15. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v2.30 | RPS15 | Eleanor Williams commented on gene: RPS15 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility | RPS15 | Clare Turnbull reviewed RPS15 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||