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| Haematological malignancies cancer susceptibility v1.14 | UNC13D | Ellen McDonagh Added comment: Comment on mode of inheritance: Biallelic variants caused Hemophagocytic lymphohistiocytosis, familial, 3, whereas heterozygous variants in this gene have been associated with increased risk of lymphoma in PMID: 30758854, and with childhood leukemia in PMID 21370424. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.14 | UNC13D | Ellen McDonagh Mode of inheritance for gene: UNC13D was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.9 | UNC13D | Ellen McDonagh Classified gene: UNC13D as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.9 | UNC13D | Ellen McDonagh Added comment: Comment on list classification: Promoted to Amber for review. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.9 | UNC13D | Ellen McDonagh Gene: unc13d has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.5 | UNC13D | Ellen McDonagh Publications for gene UNC13D were changed from 30758854; 24309606; 21370424 to 30758854; 24309606; 21370424; 24827398 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v1.4 | UNC13D |
Ellen McDonagh gene: UNC13D was added gene: UNC13D was added to Haematological malignancies cancer susceptibility. Sources: Expert list,Literature Mode of inheritance for gene: UNC13D was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: UNC13D were set to 30758854; 24309606; 21370424 Phenotypes for gene: UNC13D were set to Increased risk of lymphoma; predisposition to childhood anaplastic large cell lymphoma; predisposition to leukemia; increased susceptibility to malignancy Added comment: Gene on a gene list submitted by Clare Turnbull. Sources: Expert list, Literature |
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