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Long QT syndrome v2.31 KCNE2 Ivone Leong Tag for-review was removed from gene: KCNE2.
Long QT syndrome v2.31 KCNE2 Ivone Leong commented on gene: KCNE2: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Long QT syndrome v2.30 KCNE2 Ivone Leong Source Expert Review Amber was added to KCNE2.
Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
Long QT syndrome v2.7 KCNE2 Ivone Leong Tag for-review tag was added to gene: KCNE2.
Long QT syndrome v2.6 KCNE2 Zornitza Stark reviewed gene: KCNE2: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Long QT syndrome 6, MIM# 613693; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Long QT syndrome v1.44 KCNE2 Ivone Leong reviewed gene: KCNE2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Long QT syndrome v1.34 KCNE2 Ivone Leong Phenotypes for gene: KCNE2 were changed from Long QT syndrome-6 (613693); Long QT syndrome-6 ; Atrial fibrillation, familial, 4 (611493) to Long QT syndrome 6 (613693); Atrial fibrillation, familial, 4 (611493)
Long QT syndrome v1.33 KCNE2 Ivone Leong Publications for gene: KCNE2 were set to 19716085
Long QT syndrome v1.26 KCNE2 Rebecca Whittington commented on gene: KCNE2: Atrial fibrillation, familial, 4 (OMIM 611493), Long QT syndrome 6 (OMIM 613693)
Long QT syndrome v1.25 KCNE2 Rebecca Whittington commented on gene: KCNE2: Literature/functional evidence for this gene. PMID:19716085. PMID:27465075. PMID:20042375.
Long QT syndrome v1.24 KCNE2 Rebecca Whittington reviewed gene: KCNE2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Long QT syndrome v1.23 KCNE2 Matthew Edwards reviewed gene: KCNE2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Long QT syndrome-6 (613693), Atrial fibrillation, familial, 4 (611493); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Long QT syndrome v1.16 KCNE2 Ellen McDonagh Source South West GLH was added to KCNE2.
Long QT syndrome v1.15 KCNE2 Ellen McDonagh edited their review of gene: KCNE2: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER
Long QT syndrome v1.14 KCNE2 Ellen McDonagh Source London South GLH was added to KCNE2.
Long QT syndrome v1.13 KCNE2 James Eden reviewed gene: KCNE2: Rating: GREEN; Mode of pathogenicity: ; Publications: 19716085; Phenotypes: Long QT syndrome-6 (613693), Atrial fibrillation, familial, 4 (611493); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Long QT syndrome v1.12 KCNE2 Ellen McDonagh Source North West GLH was added to KCNE2.
Added phenotypes Long QT syndrome-6 (613693); Atrial fibrillation, familial, 4 (611493) for gene: KCNE2
Publications for gene KCNE2 were changed from to 19716085
Rating Changed from Green List (high evidence) to Green List (high evidence)
Long QT syndrome v1.10 KCNE2 Oxford Medical Genetics Laboratory edited their review of gene: KCNE2: Added comment: Very little genetic variation in this gene. No significant evidence of pathogenic variants in this gene according to todays classification standards but it remains a good functional candidate. Happy for it to remain on the LQT panel. ; Changed rating: AMBER