DOCK11

dedicator of cytokinesis 11
OMIM: 300681, Gene2Phenotype

2 panels

Panel	Reviews	Mode of inheritance	Details
Green DOCK11 in Primary immunodeficiency or monogenic inflammatory bowel disease Version 5.3 Latest signed off version: v5.0 (1 May 2024)	review	X-LINKED: hemizygous mutation in males, biallelic mutations in females	Sources Expert Review Green NHS GMS Literature Phenotypes Autoinflammatory disease, multisystem, with immune dysregulation, X-linked, OMIM:301109
Red DOCK11 in Intellectual disability Level 3: Neurodevelopmental disorders Level 2: Neurology and neurodevelopmental disorders Version 6.12 Latest signed off version: v6.0 (1 May 2024) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Sources Expert Review Red

Panel

Reviews

Mode of inheritance

Details

Green DOCK11 in Primary immunodeficiency or monogenic inflammatory bowel disease

Version 5.3
Latest signed off version: v5.0 (1 May 2024)

review

X-LINKED: hemizygous mutation in males, biallelic mutations in females

Sources

Expert Review Green
NHS GMS
Literature

Phenotypes

Autoinflammatory disease, multisystem, with immune dysregulation, X-linked, OMIM:301109

Red DOCK11 in Intellectual disability

Level 3: Neurodevelopmental disorders
Level 2: Neurology and neurodevelopmental disorders
Version 6.12
Latest signed off version: v6.0 (1 May 2024)

Component of the following Super Panels:

Childhood onset leukodystrophy

Hypotonic infant

Paediatric disorders

review

X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Sources

Expert Review Red