MT-ND4

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
OMIM: 516003, Gene2Phenotype

10 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 10 panels
Green MT-ND4 in Gene therapy clinical trials Level 3: Clinical trials Level 2: Actionable information Version 0.9	review	Not set	Sources Expert Review Green ClinicalTrials.gov Phenotypes Optic, Atrophy, Hereditary, Leber
Green MT-ND4 in Leber hereditary optic neuropathy Version 2.9 Latest signed off version: v2.5 (22 Mar 2023)	review	MITOCHONDRIAL	Sources Expert List Expert Review Green Phenotypes Leber's hereditary optic neuropathy Tags gene-checked
Green MT-ND4 in Optic neuropathy Level 3: Posterior segment abnormalities Level 2: Ophthalmological disorders Version 4.30 Latest signed off version: v4.0 (22 Mar 2023)	review	MITOCHONDRIAL	Sources London North GLH Expert Review Green UKGTN Phenotypes Leber's hereditary optic neuropathy Tags gene-therapy-trial gene-checked
Green MT-ND4 in Undiagnosed metabolic disorders Level 3: Specific metabolic abnormalities Level 2: Metabolic disorders Version 1.617	review	MITOCHONDRIAL	Sources Expert Review Green Phenotypes LEBER OPTIC ATROPHY MELAS SYNDROME LEBER OPTIC ATROPHY AND DYSTONIA MITOCHONDRIAL COMPLEX I DEFICIENCY Tags gene-therapy-trial gene-checked
Green MT-ND4 in Likely inborn error of metabolism - targeted testing not possible Version 4.137 Latest signed off version: v4.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	MITOCHONDRIAL	Sources Expert Review Green Phenotypes MELAS SYNDROME LEBER OPTIC ATROPHY AND DYSTONIA LEBER OPTIC ATROPHY MITOCHONDRIAL COMPLEX I DEFICIENCY Tags gene-checked
Red MT-ND4 in Intellectual disability - microarray and sequencing Level 3: Neurodevelopmental disorders Level 2: Neurology and neurodevelopmental disorders Version 5.532 Latest signed off version: v5.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	MITOCHONDRIAL	Sources Expert Review Red Expert Review Red Expert Review Amber BRIDGE study SPEED NEURO Tier1 Gene Phenotypes Mitochondrial complex I deficiency autism spectrum disorder intellectual disability Tags cnv
Green MT-ND4 in Mitochondrial disorders Level 3: Mitochondrial Level 2: Metabolic disorders Version 4.168 Latest signed off version: v4.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy	review	MITOCHONDRIAL	Sources Expert Review Green UKGTN Phenotypes LEBER OPTIC ATROPHY MELAS SYNDROME LEBER OPTIC ATROPHY AND DYSTONIA MITOCHONDRIAL COMPLEX I DEFICIENCY Tags gene-therapy-trial gene-checked
Red MT-ND4 in Retinal disorders Level 3: Posterior segment abnormalities Level 2: Ophthalmological disorders Version 4.89 Latest signed off version: v4.0 (22 Mar 2023)	review	MITOCHONDRIAL	Sources NHS GMS Expert Review Red
No list MT-ND4 in Childhood onset dystonia, chorea or related movement disorder Version 3.75 Latest signed off version: v3.0 (22 Mar 2023)	review	MITOCHONDRIAL	Sources Expert Review Removed London North GLH Phenotypes Leber Optic Atrophy And Dystonia Tags curated_removed
Green MT-ND4 in Severe Paediatric Disorders Version 1.184	review	MITOCHONDRIAL	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes LEBER OPTIC ATROPHY LEBER OPTIC ATROPHY AND DYSTONIA MITOCHONDRIAL COMPLEX I DEFICIENCY MELAS SYNDROME