SDHAF2

succinate dehydrogenase complex assembly factor 2
OMIM: 613019, Gene2Phenotype

12 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 12 panels
Green SDHAF2 in Neuroendocrine cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.5	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Neuroendocrine cancer
Green SDHAF2 in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.42	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Familial Paraganglioma and Pheochromocytoma
Green SDHAF2 in Multiple endocrine tumours Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.15	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Endocrine Cancer familial paraganglioma
Green SDHAF2 in Inherited phaeochromocytoma and paraganglioma Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.12	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Eligibility statement prior genetic testing Illumina TruGenome Clinical Sequencing Services UKGTN Emory Genetics Laboratory Radboud University Medical Center, Nijmegen Phenotypes Paragangliomas 2, 601650 Hereditary Paraganglioma-Pheochromocytoma Syndrome
Green SDHAF2 in Inherited phaeochromocytoma and paraganglioma excluding NF1 Level 2: Endocrinology Version 3.10 Latest signed off version: v3.0 (7 Aug 2024)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Phenotypes Paragangliomas 2, 601650 Hereditary Paraganglioma-Pheochromocytoma Syndrome
Green SDHAF2 in Adult solid tumours cancer susceptibility Level 2: Cancer susceptibility Version 2.35 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Familial Paraganglioma and Pheochromocytoma
Amber SDHAF2 in Mitochondrial disorder with complex II deficiency Level 2: Mitochondrial Version 2.11 Latest signed off version: v2.2 (22 Mar 2023)	review	Unknown	Sources Expert Review Amber NHS GMS Phenotypes No OMIM phenotype
Amber SDHAF2 in Undiagnosed metabolic disorders Level 3: Specific metabolic abnormalities Level 2: Metabolic disorders Version 1.642	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Amber Literature Phenotypes Complex II (Mitochondrial respiratory chain disorders (caused by nuclear variants only), OXPHOS assembly factors) Multiple endocrine tumours Multiple Tumours Neuro-endocrine Tumours- PCC and PGL
Amber SDHAF2 in Likely inborn error of metabolism Level 2: Metabolic Version 8.91 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources London North GLH NHS GMS Expert Review Amber Phenotypes Mitochondrial Diseases Isolated complex II deficiency Complex II (Mitochondrial respiratory chain disorders (caused by nuclear variants only), OXPHOS assembly factors) Neuro-endocrine Tumours- PCC and PGL Multiple endocrine tumours Multiple Tumours
Amber SDHAF2 in Possible mitochondrial disorder - nuclear genes Level 2: Mitochondrial Version 4.20 Latest signed off version: v4.0 (30 Apr 2025)	review	Unknown	Sources Expert Review Amber NHS GMS Phenotypes No OMIM phenotype
Red SDHAF2 in Mitochondrial disorders Level 2: Mitochondrial Version 9.41 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy	review	Not set	Sources Expert list Expert Emory Genetics Laboratory Phenotypes Mitochondrial Diseases Isolated complex II deficiency
Red SDHAF2 in Childhood onset dystonia, chorea or related movement disorder Level 2: Neurology Version 7.13 Latest signed off version: v7.0 (30 Apr 2025)	review	Not set	Sources Expert Review Red London North GLH