1. Genes and Genomic Entities
  2. SDHB

SDHB

succinate dehydrogenase complex iron sulfur subunit B
OMIM: 185470, Gene2Phenotype

22 panels

Panel Reviews Mode of inheritance Details
22 panels
Red SDHB in Inherited non-medullary thyroid cancer

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.8

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Cowden syndrome 2 612359
Red SDHB in Genodermatoses with malignancies

Level 3: Skin
Level 2: Tumour syndromes
Version 1.11

review Not set
Sources
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Gastrointestinal stromal tumor, OMIM:606764
  • Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green SDHB in Neuroendocrine cancer pertinent cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.5

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Paragangliomas 4, OMIM:115310
  • Pheochromocytoma, OMIM:171300
  • Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green SDHB in Renal cancer pertinent cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.3

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Paragangliomas 4, OMIM:115310
  • Pheochromocytoma, OMIM:171300
  • Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green SDHB in Adult solid tumours for rare disease

Level 3: Tumour syndromes
Level 2: Tumour syndromes
Version 1.42

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert list
  • Expert Review Green
Phenotypes
  • Paragangliomas 4, OMIM:115310
  • Pheochromocytoma, OMIM:171300
  • Paraganglioma and gastric stromal sarcoma, OMIM:606864
  • Gastrointestinal stromal tumor, OMIM:606764
Green SDHB in White matter disorders and cerebral calcification - narrow panel


Level 2: Neurology
Version 7.19
Latest signed off version: v7.0 (30 Apr 2025)

Component of the following Super Panels:

  • Childhood onset leukodystrophy

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Red SDHB in Childhood solid tumours


    Level 2: Cancer susceptibility
    Version 5.10
    Latest signed off version: v5.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    • Gastrointestinal stromal tumor, OMIM:606764
    Green SDHB in Inherited renal cancer


    Level 2: Inherited cancer
    Version 1.28
    Latest signed off version: v1.2 (4 Mar 2020)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert List
    • UKGTN
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    Green SDHB in Inherited predisposition to GIST


    Level 2: Inherited cancer
    Version 1.15
    Latest signed off version: v1.2 (4 Mar 2020)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • Expert List
    Phenotypes
    • Gastrointestinal stromal tumor, OMIM:606764
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    • Carney-Stratakis syndrome, MONDO:0011740
    Green SDHB in Multiple endocrine tumours

    Level 3: Breast and endocrine
    Level 2: Tumour syndromes
    Version 1.15

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Emory Genetics Laboratory
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    Green SDHB in Inherited phaeochromocytoma and paraganglioma

    Level 3: Breast and endocrine
    Level 2: Tumour syndromes
    Version 1.12

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Eligibility statement prior genetic testing
    • UKGTN
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    • Illumina TruGenome Clinical Sequencing Services
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    Green SDHB in Inherited phaeochromocytoma and paraganglioma excluding NF1


    Level 2: Endocrinology
    Version 3.10
    Latest signed off version: v3.0 (7 Aug 2024)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    Green SDHB in Inherited white matter disorders

    Level 3: White matter disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.186

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Amber SDHB in Sarcoma cancer susceptibility

    Level 3: Pertinent cancer susceptibility gene panel
    Level 2: Cancer Programme
    Version 1.26

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Expert List
    Green SDHB in Adult solid tumours cancer susceptibility


    Level 2: Cancer susceptibility
    Version 2.35
    Latest signed off version: v2.2 (18 Feb 2020)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • NHS GMS
    • Expert Review Green
    • Expert list
    Phenotypes
    • Paragangliomas 4, OMIM:115310
    • Pheochromocytoma, OMIM:171300
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    • Gastrointestinal stromal tumor, OMIM:606764
    Green SDHB in Mitochondrial disorder with complex II deficiency


    Level 2: Mitochondrial
    Version 2.11
    Latest signed off version: v2.2 (22 Mar 2023)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Green SDHB in Undiagnosed metabolic disorders

    Level 3: Specific metabolic abnormalities
    Level 2: Metabolic disorders
    Version 1.643

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Green SDHB in Likely inborn error of metabolism


    Level 2: Metabolic
    Version 8.103
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • London North GLH
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Green SDHB in Possible mitochondrial disorder - nuclear genes


    Level 2: Mitochondrial
    Version 4.23
    Latest signed off version: v4.0 (30 Apr 2025)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Green SDHB in Mitochondrial disorders


    Level 2: Mitochondrial
    Version 9.46
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • NHS GMS
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    • Expert list
    • Expert
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
    Amber SDHB in Sarcoma susceptibility


    Level 2: Cancer susceptibility
    Version 1.82
    Latest signed off version: v1.2 (18 Feb 2020)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • NHS GMS
    • Expert Review Amber
    • Expert Review Amber
    • Expert List
    Phenotypes
    • Paraganglioma and gastric stromal sarcoma, OMIM:606864
    • Carney-Stratakis syndrome, MONDO:0011740
    Red SDHB in Childhood onset dystonia, chorea or related movement disorder


    Level 2: Neurology
    Version 7.18
    Latest signed off version: v7.0 (30 Apr 2025)

    		review Not set
    Sources
    • Expert Review Red
    • London North GLH