Head and neck cancer pertinent cancer susceptibility
Gene: SLX4
SLX4 (SLX4 structure-specific endonuclease subunit)
EnsemblGeneIds (GRCh38): ENSG00000188827
EnsemblGeneIds (GRCh37): ENSG00000188827
OMIM: 613278, Gene2Phenotype
SLX4 is in 18 panels
EnsemblGeneIds (GRCh38): ENSG00000188827
EnsemblGeneIds (GRCh37): ENSG00000188827
OMIM: 613278, Gene2Phenotype
SLX4 is in 18 panels
1 review
Ellen McDonagh (Genomics England Curator)
Comment on list classification: Promoted to Green for inclusion in the germline pipeline for head and neck cancer.Created: 20 Aug 2018, 1:22 p.m.
This gene was suggested by Lara Hawkes (Cancer Clinical Team, Genomics England) to be added to this panel, from the Haematological malignancies pertinent cancer susceptibility gene panel.Created: 20 Aug 2018, 1:21 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Class: BM failure FA, (typ AR); Fanconi anemia; MDS; AML; Bone marrow failure; Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- Expert list
- Phenotypes
-
- Class: BM failure FA, (typ AR)
- Fanconi anemia
- MDS
- AML
- Bone marrow failure
- Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
- OMIM
- 613278
- Clinvar variants
- Variants in SLX4
- Penetrance
- None
- Publications
- Panels with this gene
-
- Cytopenias and congenital anaemias
- Limb disorders
- DDG2P
- Haematological malignancies cancer susceptibility
- Pigmentary skin disorders
- Monogenic short stature
- COVID-19 research
- Neurofibromatosis Type 1
- Haematological malignancies for rare disease
- Confirmed Fanconi anaemia or Bloom syndrome
- Childhood solid tumours
- Head and neck cancer pertinent cancer susceptibility
- Adult solid tumours cancer susceptibility
- Fetal anomalies
- Severe microcephaly
- Childhood solid tumours cancer susceptibility
- Radial dysplasia
- Intellectual disability
History Filter Activity
7 Sep 2018, Gel status: 3
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Ellen McDonagh: This gene was suggested by Lar
20 Aug 2018, Gel status: 3
Entity classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)Gene: slx4 has been classified as Green List (High Evidence).
20 Aug 2018, Gel status: 1
Added New Source
Ellen McDonagh (Genomics England Curator)SLX4 was added to Head and neck cancer pertinent cancer susceptibility panel. Sources: Expert list
20 Aug 2018, Gel status: 1
Created
Ellen McDonagh (Genomics England Curator)SLX4 was created by Ellen McDonagh