Melanoma pertinent cancer susceptibilityGene: CDK4
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for Malignant Melanoma.
Created: 26 Jul 2017, 11:55 a.m.
Comment on mode of pathogenicity: Activating variants.
Created: 19 Jul 2017, 3:38 p.m.
Ellen McDonagh: Comment on mode of pathogenici
This gene has been classified as Green List (High Evidence).
Mode of pathogenicity for CDK4 was changed to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
CDK4 was added to Melanomapanel. Sources: Expert list
CDK4 was created by ellenmcdonagh