CDK4

cyclin dependent kinase 4
OMIM: 123829, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels
Green CDK4 in Melanoma pertinent cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.3

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Malignant Melanoma
Green CDK4 in Adult solid tumours for rare disease

Level 3: Tumour syndromes
Level 2: Tumour syndromes
Version 1.42

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Hereditary Melanoma
Green CDK4 in Familial melanoma


Level 2: Inherited cancer
Version 2.16
Latest signed off version: v2.15 (12 Aug 2026)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • NHS GMS
  • Expert List
Amber CDK4 in Inherited pancreatic cancer


Level 2: Inherited cancer
Version 3.5
Latest signed off version: v3.4 (12 Aug 2026)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
Phenotypes
  • Malignant pancreatic neoplasm, MONDO:0009831
Green CDK4 in Pigmentary skin disorders


Level 2: Dermatology
Version 5.19
Latest signed off version: v5.12 (12 Aug 2026)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3
  • Melanoma susceptibility
  • CMM3
No list CDK4 in Multiple monogenic benign skin tumours


Level 2: Dermatology
Version 2.8
Latest signed off version: v2.7 (12 Aug 2026)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Removed
  • London North GLH
  • NHS GMS
Phenotypes
  • Melanoma susceptibility
Tags
  • curated_removed
Green CDK4 in Adult solid tumours cancer susceptibility


Level 2: Cancer susceptibility
Version 2.40
Latest signed off version: v2.2 (18 Feb 2020)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
  • Expert list
Phenotypes
  • Hereditary Melanoma
Amber CDK4 in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 8.26
Latest signed off version: v8.0 (12 Aug 2026)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Amber
Phenotypes
  • microcephaly 31, primary, autosomal recessive, MONDO:0980991
  • Short stature, HP:0004322
  • Microcephaly 31, primary, autosomal recessive, OMIM:621507