Inherited pancreatic cancer
Gene: CDK4Comment on phenotypes: This gene is also associated with {Melanoma, cutaneous malignant, 3} (MIM# 609048)Created: 3 Mar 2021, 2:25 p.m. | Last Modified: 3 Mar 2021, 2:25 p.m.
Panel Version: 1.10
Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.Created: 1 Feb 2019, 10:12 a.m.
Publications
Variants in this GENE are reported as part of current diagnostic practice
Gain of functionCreated: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Hereditary Melanoma
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype -please provide details in the comments
Phenotypes for gene: CDK4 were changed from to Malignant pancreatic neoplasm, MONDO:0009831
Mode of pathogenicity for gene: CDK4 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Publications for gene: CDK4 were set to
Gene: cdk4 has been classified as Amber List (Moderate Evidence).
Mode of inheritance for gene: CDK4 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: cdk4 has been classified as Green List (High Evidence).
gene: CDK4 was added gene: CDK4 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: CDK4 was set to