Inherited pancreatic cancer
Gene: BRCA1
The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 8 Mar 2022, 11:56 a.m. | Last Modified: 8 Mar 2022, 11:56 a.m.
Panel Version: 1.20
Comment on phenotypes: This gene is also associated with {Breast-ovarian cancer, familial, 1} (MIM# 604370) and Fanconi anemia, complementation group S (MIM# 617883)Created: 3 Mar 2021, 2:10 p.m. | Last Modified: 3 Mar 2021, 2:10 p.m.
Panel Version: 1.8
Publications
Variants in this GENE are reported as part of current diagnostic practice
Comment on mode of inheritance: Changed from monoallelic to 'both' monoallelic and biallelic, due to feedback from Lara Hawkes and Clare Turnbull (Cancer Clinical Team, Genomics England); biallelic variants in this gene cause Fanconi anemia, complementation group S, whereas monoallelic variants confer susceptibility to Breast-ovarian cancer, familial, 1.Created: 20 Aug 2018, 11:53 a.m.
Tumor Suppressor. Biallelic phenotype.Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Hereditary Breast and Ovarian Cancer
Source Expert Review Green was added to BRCA1. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Phenotypes for gene: BRCA1 were changed from to {Pancreatic cancer, susceptibility to, 4}, OMIM:614320; Pancreatic cancer, susceptibility to, 4, MONDO:0013685
Publications for gene: BRCA1 were set to
Mode of inheritance for gene: BRCA1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: brca1 has been classified as Amber List (Moderate Evidence).
gene: BRCA1 was added gene: BRCA1 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: BRCA1 was set to