Inherited pancreatic cancerGene: STK11
Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated red.
Created: 1 Feb 2019, 10:13 a.m.
Variants in this GENE are reported as part of current diagnostic practice
Comment on mode of pathogenicity: Confirmed with Clare Turnbull that loss-of-function variants should be reported in this gene.
Created: 16 Mar 2018, 9:48 a.m.
Tumor Suppressor. Gain of function.
Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Peutz Jeghers syndrome
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype -please provide details in the comments
Phenotypes for gene: STK11 were changed from to Pancreatic cancer, somatic, OMIM:260350
Publications for gene: STK11 were set to
Gene: stk11 has been classified as Red List (Low Evidence).
Mode of inheritance for gene: STK11 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: stk11 has been classified as Green List (High Evidence).
gene: STK11 was added gene: STK11 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: STK11 was set to