Familial melanomaGene: CDK4
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
Created: 31 Jul 2019, 12:54 p.m. | Last Modified: 31 Jul 2019, 12:54 p.m.
Panel Version: 0.23
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for Malignant Melanoma.
Created: 26 Jul 2017, 11:55 a.m.
Comment on mode of pathogenicity: Activating variants.
Created: 19 Jul 2017, 3:38 p.m.
Mode of inheritance for gene: CDK4 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: cdk4 has been classified as Green List (High Evidence).
gene: CDK4 was added gene: CDK4 was added to Familial melanoma. Sources: Expert List,NHS GMS Mode of inheritance for gene: CDK4 was set to