Dilated Cardiomyopathy (DCM)
Gene: TTNComment when marking as ready: On Manchester diagnostic panel; ideally ignore missense variationCreated: 11 Feb 2016, 2:24 p.m.
Truncating variants in A-band region detected in 12-15% of DCM patients. However, also detected in ~0.5% of control individuals. Very strong evidence for A-band truncating variants as a whole, but little evidence (esp. segregation) for most such variants when considered individually, due to reduced penetrance. The significance of missense changes is largely unknown.Created: 6 Jan 2016, 5:12 p.m.
Variants in this GENE are reported as part of current diagnostic practice
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: Eligibility statement prior genetic testing
Mode of inheritance for TTN was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mode of inheritance for TTN was changed to BIALLELIC, autosomal or pseudoautosomal
Mode of inheritance for TTN was changed to BIALLELIC, autosomal or pseudoautosomal
This gene has been classified as Green List (High Evidence).
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: UKGTN
Model of inheritance for gene TTN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Emory Genetics Laboratory,Expert list
Model of inheritance for gene TTN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Emory Genetics Laboratory,Expert list
Model of inheritance for gene TTN was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Emory Genetics Laboratory,Expert list
TTN was added to Dilated Cardiomyopathy (DCM)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Emory Genetics Laboratory,Expert list