Familial diabetes
Gene: DYRK1B

DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B)
EnsemblGeneIds (GRCh38): ENSG00000105204
EnsemblGeneIds (GRCh37): ENSG00000105204
OMIM: 604556, Gene2Phenotype
DYRK1B is in 3 panels

1 review

Ivone Leong (Genomics England Curator)

Green List (high evidence)

Comment on list classification: Promoted from red to green as advised via email communication with Jane Houghton (South West GLH).
Created: 28 Jan 2019, 9:39 a.m.

Initial gene list and info collated by Sian Ellard, University of Exeter Medical School, August 2018 on behalf of the GMS Endocrinology specialist test group. Gene Symbol submitted: DYRK1B; Suggested intial gene rating: Green; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given; Phenotypes: Metabolic syndrome (coronary artery disease, hypertension, central obesity and diabetes).
Created: 11 Jan 2019, 10:04 a.m.

Created: 11 Jan 2019, 10:04 a.m.

Panel version: Imported from Monogenic diabetes panel version 0.8

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS
Expert Review Green
Expert Review Green
NHS GMS

Phenotypes

Abdominal obesity-metabolic syndrome 3, 615812

OMIM

604556

Clinvar variants

Variants in DYRK1B

Penetrance

None

Panels with this gene

History Filter Activity

1 Mar 2019, Gel status: 4

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: DYRK1B were changed from to Abdominal obesity-metabolic syndrome 3, 615812

1 Mar 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: DYRK1B was added gene: DYRK1B was added to Familial diabetes. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: DYRK1B was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Familial diabetes Gene: DYRK1B