1. Panels
  2. Primary ovarian insufficiency
  3. NOBOX
STRs in panel
Prev Next
Regions in panel
Prev Next

Primary ovarian insufficiency

Gene: NOBOX

Green List (high evidence)
NOBOX (NOBOX oogenesis homeobox)
EnsemblGeneIds (GRCh38): ENSG00000106410
EnsemblGeneIds (GRCh37): ENSG00000106410
OMIM: 610934, Gene2Phenotype
NOBOX is in 1 panel

3 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Clear cause of POI in some affected individuals.
Created: 9 Jun 2017, 3:24 p.m.

Publications

Created: 9 Jun 2017, 3:24 p.m.

Panel version: 1.0

Arianna Tucci (Genomics England Curator)

Green List (high evidence)

Associated with phenotype in OMIM; more than 3 variants described
Created: 10 May 2017, 11:45 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Premature ovarian failure 5, 611548

Publications

Created: 10 May 2017, 11:45 a.m.

Panel version: 0.6

Ellen McDonagh (Genomics England Curator)

This gene is also on The University of Chicago Genetic Services Laboratories Next Generation Sequencing Panel for Premature Ovarian Failure.
Created: 13 Jun 2016, 2:39 p.m.
Created: 13 Jun 2016, 2:39 p.m.

Panel version: 0.2

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Other
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Premature ovarian failure 5,611548
  • Premature Ovarian Failure
OMIM
610934
Clinvar variants
Variants in NOBOX
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

31 May 2017, Gel status: 4

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoting to Version 1 on 31-05-2017, after internal curation and review.

22 May 2017, Gel status: 4

Gene classified by Genomics England curator

Arianna Tucci (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

22 May 2017, Gel status: 4

Set Phenotypes

Arianna Tucci (Genomics England Curator)

Phenotypes for NOBOX were set to Premature ovarian failure 5,611548; Premature Ovarian Failure

22 May 2017, Gel status: 4

Set publications

Arianna Tucci (Genomics England Curator)

Publications for NOBOX were set to 25514101

22 May 2017, Gel status: 4

Set Mode of Inheritance

Arianna Tucci (Genomics England Curator)

Mode of inheritance for NOBOX was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

22 May 2017, Gel status: 4

Gene classified by Genomics England curator

Arianna Tucci (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

13 Jun 2016, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

NOBOX was added to Early onset familial premature ovarian insufficiencypanel. Source: Other

13 Jun 2016, Gel status: 2

Set Mode of Inheritance, Added New Source

Ellen McDonagh (Genomics England Curator)

NOBOX was added to Early onset familial premature ovarian insufficiencypanel. Source: Illumina TruGenome Clinical Sequencing Services Model of inheritance for gene NOBOX was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

13 Jun 2016, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

NOBOX was added to Early onset familial premature ovarian insufficiencypanel. Sources: Radboud University Medical Center, Nijmegen

13 Jun 2016, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

NOBOX was created by ellenmcdonagh